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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TGFB3_HUMAN (P10600)

Summary

This is the summary of UniProt entry TGFB3_HUMAN (P10600).

Description: Transforming growth factor beta-3 proprotein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 412 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 23
low_complexity n/a 21 30
Pfam TGFb_propeptide 24 259
low_complexity n/a 77 90
disorder n/a 83 96
disorder n/a 167 168
disorder n/a 184 187
disorder n/a 259 268
disorder n/a 289 295
Pfam TGF_beta 314 411

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P10600. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK
50
51
LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY
100
101
YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE
150
151
FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL
200
201
SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF
250
251
KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR
300
301
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY
350
351
LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ
400
401
LSNMVVKSCK CS                                         
412
 

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Checksums:
CRC64:3CAD3548D3AEA178
MD5:164c2b5f852359fc60471560ae57295c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TGF_beta 314 - 411 1KTZ A 14 - 111 NGL View in InterPro
1TGJ A 14 - 111 NGL View in InterPro
1TGK A 14 - 111 NGL View in InterPro
2PJY A 14 - 111 NGL View in InterPro
3EO1 C 14 - 111 NGL View in InterPro
F 14 - 111 NGL View in InterPro
I 14 - 111 NGL View in InterPro
L 14 - 111 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.