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35  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HSP7C_HUMAN (P11142)

Summary

This is the summary of UniProt entry HSP7C_HUMAN (P11142).

Description: Heat shock cognate 71 kDa protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 646 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam HSP70 6 612
disorder n/a 55 56
low_complexity n/a 368 378
low_complexity n/a 391 401
low_complexity n/a 418 430
disorder n/a 424 428
disorder n/a 442 443
disorder n/a 461 462
disorder n/a 472 473
disorder n/a 497 510
disorder n/a 512 541
coiled_coil n/a 512 535
disorder n/a 553 566
disorder n/a 582 598
disorder n/a 611 646
low_complexity n/a 613 640

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P11142. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL
50
51
IGDAAKNQVA MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR
100
101
PKVQVEYKGE TKSFYPEEVS SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF
150
151
NDSQRQATKD AGTIAGLNVL RIINEPTAAA IAYGLDKKVG AERNVLIFDL
200
201
GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH FIAEFKRKHK
250
251
KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA
300
301
RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL
350
351
QDFFNGKELN KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS
400
401
LGIETAGGVM TVLIKRNTTI PTKQTQTFTT YSDNQPGVLI QVYEGERAMT
450
451
KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI DANGILNVSA VDKSTGKENK
500
501
ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN SLESYAFNMK
550
551
ATVEDEKLQG KINDEDKQKI LDKCNEIINW LDKNQTAEKE EFEHQQKELE
600
601
KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD    
646
 

Show the unformatted sequence.

Checksums:
CRC64:9AA27B210730670C
MD5:d7bc28ba69da98a3ee84d089f67f05e4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HSP70 541 - 612 4KBQ C 541 - 612 NGL View in InterPro
D 541 - 612 NGL View in InterPro
6 - 380 5AQG E 6 - 380 NGL View in InterPro
5AQT A 6 - 380 NGL View in InterPro
6 - 381 3FZF A 6 - 381 NGL View in InterPro
3FZH A 6 - 381 NGL View in InterPro
3FZK A 6 - 381 NGL View in InterPro
3FZL A 6 - 381 NGL View in InterPro
3FZM A 6 - 381 NGL View in InterPro
3LDQ A 6 - 381 NGL View in InterPro
3M3Z A 6 - 381 NGL View in InterPro
4HWI A 6 - 381 NGL View in InterPro
5AQF A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
5AQG A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
5AQH A 6 - 381 NGL View in InterPro
5AQI A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
5AQJ A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
E 6 - 381 NGL View in InterPro
5AQK A 6 - 381 NGL View in InterPro
5AQL A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
5AQM A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
5AQN A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
E 6 - 381 NGL View in InterPro
5AQO A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
E 6 - 381 NGL View in InterPro
5AQP A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
E 6 - 381 NGL View in InterPro
5AQQ A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
E 6 - 381 NGL View in InterPro
5AQR A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
E 6 - 381 NGL View in InterPro
5AQS A 6 - 381 NGL View in InterPro
C 6 - 381 NGL View in InterPro
5AQU A 6 - 381 NGL View in InterPro
5AQV A 6 - 381 NGL View in InterPro
6B1I A 6 - 381 NGL View in InterPro
B 6 - 381 NGL View in InterPro
6B1M A 6 - 381 NGL View in InterPro
B 6 - 381 NGL View in InterPro
6B1N A 6 - 381 NGL View in InterPro
B 6 - 381 NGL View in InterPro
6 - 384 4H5N A 6 - 384 NGL View in InterPro
B 6 - 384 NGL View in InterPro
4H5R A 6 - 384 NGL View in InterPro
B 6 - 384 NGL View in InterPro
4H5T A 6 - 384 NGL View in InterPro
4H5V A 6 - 384 NGL View in InterPro
4H5W A 6 - 384 NGL View in InterPro
B 6 - 384 NGL View in InterPro
6ZYJ A 6 - 384 NGL View in InterPro
B 6 - 384 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;