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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IMDH2_HUMAN (P12268)

Summary

This is the summary of UniProt entry IMDH2_HUMAN (P12268).

Description: Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 514 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam IMPDH 29 504
Pfam CBS 107 166
Pfam CBS 175 232

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12268. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD
50
51
LTSALTKKIT LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ
100
101
ANEVRKVKKY EQGFITDPVV LSPKDRVRDV FEAKARHGFC GIPITDTGRM
150
151
GSRLVGIISS RDIDFLKEEE HDCFLEEIMT KREDLVVAPA GITLKEANEI
200
201
LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA KKQLLCGAAI
250
251
GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KDKYPNLQVI
300
301
GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV
350
351
SEYARRFGVP VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY
400
401
FFSDGIRLKK YRGMGSLDAM DKHLSSQNRY FSEADKIKVA QGVSGAVQDK
450
451
GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR AMMYSGELKF EKRTSSAQVE
500
501
GGVHSLHSYE KRLF                                       
514
 

Show the unformatted sequence.

Checksums:
CRC64:876BEA0EC1DDBEE9
MD5:84e20ccacc4ff78648fc01814005b9c5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CBS 107 - 109 1B3O A 107 - 109 NGL View in InterPro
107 - 110 6U8E A 107 - 110 NGL View in InterPro
B 107 - 110 NGL View in InterPro
C 107 - 110 NGL View in InterPro
D 107 - 110 NGL View in InterPro
E 107 - 110 NGL View in InterPro
F 107 - 110 NGL View in InterPro
G 107 - 110 NGL View in InterPro
H 107 - 110 NGL View in InterPro
6U8S A 107 - 110 NGL View in InterPro
B 107 - 110 NGL View in InterPro
C 107 - 110 NGL View in InterPro
D 107 - 110 NGL View in InterPro
E 107 - 110 NGL View in InterPro
F 107 - 110 NGL View in InterPro
G 107 - 110 NGL View in InterPro
H 107 - 110 NGL View in InterPro
6UA5 A 107 - 110 NGL View in InterPro
B 107 - 110 NGL View in InterPro
C 107 - 110 NGL View in InterPro
D 107 - 110 NGL View in InterPro
E 107 - 110 NGL View in InterPro
F 107 - 110 NGL View in InterPro
G 107 - 110 NGL View in InterPro
H 107 - 110 NGL View in InterPro
6UDP A 107 - 110 NGL View in InterPro
B 107 - 110 NGL View in InterPro
C 107 - 110 NGL View in InterPro
D 107 - 110 NGL View in InterPro
E 107 - 110 NGL View in InterPro
F 107 - 110 NGL View in InterPro
G 107 - 110 NGL View in InterPro
H 107 - 110 NGL View in InterPro
107 - 152 1NFB A 107 - 152 NGL View in InterPro
B 107 - 152 NGL View in InterPro
107 - 159 1B3O B 107 - 159 NGL View in InterPro
107 - 166 1NF7 A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
6I0M A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
6I0O A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
6U8N A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
6U8R A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
6U9O A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
6UA2 A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
6UA4 A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
6UAJ A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
6UC2 A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
6UDO A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
6UDQ A 107 - 166 NGL View in InterPro
B 107 - 166 NGL View in InterPro
C 107 - 166 NGL View in InterPro
D 107 - 166 NGL View in InterPro
E 107 - 166 NGL View in InterPro
F 107 - 166 NGL View in InterPro
G 107 - 166 NGL View in InterPro
H 107 - 166 NGL View in InterPro
175 - 232 1NF7 A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
6I0M A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
6I0O A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
6U8N A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
6U8R A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
6U9O A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
6UA2 A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
6UA4 A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
6UAJ A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
6UC2 A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
6UDO A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
6UDQ A 175 - 232 NGL View in InterPro
B 175 - 232 NGL View in InterPro
C 175 - 232 NGL View in InterPro
D 175 - 232 NGL View in InterPro
E 175 - 232 NGL View in InterPro
F 175 - 232 NGL View in InterPro
G 175 - 232 NGL View in InterPro
H 175 - 232 NGL View in InterPro
178 - 232 1B3O B 178 - 232 NGL View in InterPro
188 - 232 1NFB A 188 - 232 NGL View in InterPro
B 188 - 232 NGL View in InterPro
IMPDH 29 - 497 6I0O B 29 - 497 NGL View in InterPro
29 - 498 1NFB A 29 - 498 NGL View in InterPro
B 29 - 498 NGL View in InterPro
29 - 499 1B3O A 29 - 499 NGL View in InterPro
B 29 - 499 NGL View in InterPro
6I0O A 29 - 499 NGL View in InterPro
29 - 500 6UC2 A 29 - 500 NGL View in InterPro
B 29 - 500 NGL View in InterPro
C 29 - 500 NGL View in InterPro
D 29 - 500 NGL View in InterPro
E 29 - 500 NGL View in InterPro
F 29 - 500 NGL View in InterPro
G 29 - 500 NGL View in InterPro
H 29 - 500 NGL View in InterPro
29 - 501 6I0M B 29 - 501 NGL View in InterPro
29 - 502 6I0M A 29 - 502 NGL View in InterPro
29 - 504 1NF7 A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
6U8E A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6U8N A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6U8R A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6U8S A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6U9O A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6UA2 A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6UA4 A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6UA5 A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6UAJ A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6UDO A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6UDP A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
6UDQ A 29 - 504 NGL View in InterPro
B 29 - 504 NGL View in InterPro
C 29 - 504 NGL View in InterPro
D 29 - 504 NGL View in InterPro
E 29 - 504 NGL View in InterPro
F 29 - 504 NGL View in InterPro
G 29 - 504 NGL View in InterPro
H 29 - 504 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;