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24  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ODBA_HUMAN (P12694)

Summary

This is the summary of UniProt entry ODBA_HUMAN (P12694).

Description: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial EC=1.2.4.4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 445 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 34
disorder n/a 33 50
disorder n/a 89 93
Pfam E1_dh 106 406
low_complexity n/a 216 232
disorder n/a 385 387
disorder n/a 392 397
disorder n/a 400 401
disorder n/a 405 411
disorder n/a 420 422
disorder n/a 424 428

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12694. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAVAIAAARV WRLNRGLSQA ALLLLRQPGA RGLARSHPPR QQQQFSSLDD
50
51
KPQFPGASAE FIDKLEFIQP NVISGIPIYR VMDRQGQIIN PSEDPHLPKE
100
101
KVLKLYKSMT LLNTMDRILY ESQRQGRISF YMTNYGEEGT HVGSAAALDN
150
151
TDLVFGQYRE AGVLMYRDYP LELFMAQCYG NISDLGKGRQ MPVHYGCKER
200
201
HFVTISSPLA TQIPQAVGAA YAAKRANANR VVICYFGEGA ASEGDAHAGF
250
251
NFAATLECPI IFFCRNNGYA ISTPTSEQYR GDGIAARGPG YGIMSIRVDG
300
301
NDVFAVYNAT KEARRRAVAE NQPFLIEAMT YRIGHHSTSD DSSAYRSVDE
350
351
VNYWDKQDHP ISRLRHYLLS QGWWDEEQEK AWRKQSRRKV MEAFEQAERK
400
401
PKPNPNLLFS DVYQEMPAQL RKQQESLARH LQTYGEHYPL DHFDK     
445
 

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Checksums:
CRC64:2B4DD658924DB0C3
MD5:5bbc20c4dea6f07c91a2be6ee90af456

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
E1_dh 106 - 406 1DTW A 61 - 361 NGL View in InterPro
1OLS A 61 - 361 NGL View in InterPro
1OLU A 61 - 361 NGL View in InterPro
1OLX A 61 - 361 NGL View in InterPro
1U5B A 61 - 361 NGL View in InterPro
1V11 A 61 - 361 NGL View in InterPro
1V16 A 61 - 361 NGL View in InterPro
1V1M A 61 - 361 NGL View in InterPro
1V1R A 61 - 361 NGL View in InterPro
1WCI A 61 - 361 NGL View in InterPro
1X7W A 61 - 361 NGL View in InterPro
1X7X A 61 - 361 NGL View in InterPro
1X7Y A 61 - 361 NGL View in InterPro
1X7Z A 61 - 361 NGL View in InterPro
1X80 A 61 - 361 NGL View in InterPro
2BEU A 61 - 361 NGL View in InterPro
2BEV A 61 - 361 NGL View in InterPro
2BEW A 61 - 361 NGL View in InterPro
2BFB A 61 - 361 NGL View in InterPro
2BFC A 61 - 361 NGL View in InterPro
2BFD A 61 - 361 NGL View in InterPro
2BFE A 61 - 361 NGL View in InterPro
2BFF A 61 - 361 NGL View in InterPro
2J9F A 61 - 361 NGL View in InterPro
C 61 - 361 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.