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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SKI_HUMAN (P12755)

Summary

This is the summary of UniProt entry SKI_HUMAN (P12755).

Description: Ski oncogene
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 728 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 2 14
disorder n/a 22 25
low_complexity n/a 43 73
disorder n/a 58 64
low_complexity n/a 70 93
disorder n/a 71 79
Pfam Ski_Sno 84 191
disorder n/a 87 92
low_complexity n/a 202 217
Pfam c-SKI_SMAD_bind 217 311
disorder n/a 323 357
disorder n/a 380 382
disorder n/a 384 385
disorder n/a 387 388
disorder n/a 390 394
low_complexity n/a 414 425
disorder n/a 417 437
disorder n/a 440 492
low_complexity n/a 480 495
low_complexity n/a 492 509
disorder n/a 495 501
disorder n/a 503 551
low_complexity n/a 518 540
disorder n/a 553 554
disorder n/a 556 557
disorder n/a 564 565
disorder n/a 578 579
coiled_coil n/a 591 647
disorder n/a 604 608
disorder n/a 613 637
low_complexity n/a 621 632
coiled_coil n/a 660 708
low_complexity n/a 679 699
disorder n/a 685 686
disorder n/a 688 689
disorder n/a 709 728
low_complexity n/a 712 728

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12755. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEAAAGGRGC FQPHPGLQKT LEQFHLSSMS SLGGPAAFSA RWAQEAYKKE
50
51
SAKEAGAAAV PAPVPAATEP PPVLHLPAIQ PPPPVLPGPF FMPSDRSTER
100
101
CETVLEGETI SCFVVGGEKR LCLPQILNSV LRDFSLQQIN AVCDELHIYC
150
151
SRCTADQLEI LKVMGILPFS APSCGLITKT DAERLCNALL YGGAYPPPCK
200
201
KELAASLALG LELSERSVRV YHECFGKCKG LLVPELYSSP SAACIQCLDC
250
251
RLMYPPHKFV VHSHKALENR TCHWGFDSAN WRAYILLSQD YTGKEEQARL
300
301
GRCLDDVKEK FDYGNKYKRR VPRVSSEPPA SIRPKTDDTS SQSPAPSEKD
350
351
KPSSWLRTLA GSSNKSLGCV HPRQRLSAFR PWSPAVSASE KELSPHLPAL
400
401
IRDSFYSYKS FETAVAPNVA LAPPAQQKVV SSPPCAAAVS RAPEPLATCT
450
451
QPRKRKLTVD TPGAPETLAP VAAPEEDKDS EAEVEVESRE EFTSSLSSLS
500
501
SPSFTSSSSA KDLGSPGARA LPSAVPDAAA PADAPSGLEA ELEHLRQALE
550
551
GGLDTKEAKE KFLHEVVKMR VKQEEKLSAA LQAKRSLHQE LEFLRVAKKE
600
601
KLREATEAKR NLRKEIERLR AENEKKMKEA NESRLRLKRE LEQARQARVC
650
651
DKGCEAGRLR AKYSAQIEDL QVKLQHAEAD REQLRADLLR EREAREHLEK
700
701
VVKELQEQLW PRARPEAAGS EGAAELEP                        
728
 

Show the unformatted sequence.

Checksums:
CRC64:9B78C4840A28C2DA
MD5:377299115559a52118455d72d869905b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
c-SKI_SMAD_bind 219 - 311 1MR1 C 219 - 311 NGL View in InterPro
D 219 - 311 NGL View in InterPro
Ski_Sno 90 - 191 1SBX A 90 - 191 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;