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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HEM2_HUMAN (P13716)

Summary

This is the summary of UniProt entry HEM2_HUMAN (P13716).

Description: Delta-aminolevulinic acid dehydratase EC=4.2.1.24
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 330 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam ALAD 5 326
disorder n/a 88 96

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P13716. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQPQSVLHSG YFHPLLRAWQ TATTTLNASN LIYPIFVTDV PDDIQPITSL
50
51
PGVARYGVKR LEEMLRPLVE EGLRCVLIFG VPSRVPKDER GSAADSEESP
100
101
AIEAIHLLRK TFPNLLVACD VCLCPYTSHG HCGLLSENGA FRAEESRQRL
150
151
AEVALAYAKA GCQVVAPSDM MDGRVEAIKE ALMAHGLGNR VSVMSYSAKF
200
201
ASCFYGPFRD AAKSSPAFGD RRCYQLPPGA RGLALRAVDR DVREGADMLM
250
251
VKPGMPYLDI VREVKDKHPD LPLAVYHVSG EFAMLWHGAQ AGAFDLKAAV
300
301
LEAMTAFRRA GADIIITYYT PQLLQWLKEE                      
330
 

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Checksums:
CRC64:E005F3055F6D9403
MD5:b66672b117fc0309b64a1b89c7a96e3b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ALAD 11 - 326 1PV8 A 11 - 326 NGL View in InterPro
5 - 326 1E51 A 5 - 326 NGL View in InterPro
B 5 - 326 NGL View in InterPro
1PV8 B 5 - 326 NGL View in InterPro
5HMS A 5 - 326 NGL View in InterPro
B 5 - 326 NGL View in InterPro
5HNR A 5 - 326 NGL View in InterPro
B 5 - 326 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.