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48  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KPYM_HUMAN (P14618)

Summary

This is the summary of UniProt entry KPYM_HUMAN (P14618).

Description: Pyruvate kinase PKM
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 531 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 4 10
disorder n/a 13 14
Pfam PK 42 395
disorder n/a 336 339
Pfam PK_C 410 528

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P14618. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT
50
51
IGPASRSVET LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS
100
101
DPILYRPVAV ALDTKGPEIR TGLIKGSGTA EVELKKGATL KITLDNAYME
150
151
KCDENILWLD YKNICKVVEV GSKIYVDDGL ISLQVKQKGA DFLVTEVENG
200
201
GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV FASFIRKASD
250
251
VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE
300
301
IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN
350
351
AVLDGADCIM LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR
400
401
LAPITSDPTE ATAVGAVEAS FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI
450
451
IAVTRNPQTA RQAHLYRGIF PVLCKDPVQE AWAEDVDLRV NFAMNVGKAR
500
501
GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P                    
531
 

Show the unformatted sequence.

Checksums:
CRC64:AA94D7818ED6BBAD
MD5:b9f341db7edc1c70c1439f8176ea2889

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PK 42 - 395 1T5A A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
1ZJH A 41 - 394 NGL View in InterPro
3BJF A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
3BJT A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
3G2G A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
3GQY A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
3GR4 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
3H6O A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
3ME3 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
3SRD A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
3SRF A 41 - 394 NGL View in InterPro
B 41 - 394 NGL View in InterPro
C 41 - 394 NGL View in InterPro
D 41 - 394 NGL View in InterPro
E 41 - 394 NGL View in InterPro
F 41 - 394 NGL View in InterPro
G 41 - 394 NGL View in InterPro
H 41 - 394 NGL View in InterPro
3SRH A 41 - 394 NGL View in InterPro
B 41 - 394 NGL View in InterPro
C 41 - 394 NGL View in InterPro
D 41 - 394 NGL View in InterPro
3U2Z A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4B2D A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4FXF A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4FXJ A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4G1N A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4JPG A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4QG6 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4QG8 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4QG9 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4QGC A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4RPP A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4WJ8 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
4YJ5 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
5X0I A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
5X1V A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
5X1W A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6B6U A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
6GG3 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
E 42 - 395 NGL View in InterPro
F 42 - 395 NGL View in InterPro
G 42 - 395 NGL View in InterPro
H 42 - 395 NGL View in InterPro
I 42 - 395 NGL View in InterPro
J 42 - 395 NGL View in InterPro
K 42 - 395 NGL View in InterPro
L 42 - 395 NGL View in InterPro
6GG4 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6GG5 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6GG6 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
E 42 - 395 NGL View in InterPro
F 42 - 395 NGL View in InterPro
G 42 - 395 NGL View in InterPro
H 42 - 395 NGL View in InterPro
6JFB A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6NU1 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6NU5 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
6NUB A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
6TTF A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6TTH A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6TTI A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6TTQ A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6V74 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6V75 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6V76 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6WP3 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
6WP4 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6WP5 A 42 - 395 NGL View in InterPro
B 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
D 42 - 395 NGL View in InterPro
6WP6 A 42 - 395 NGL View in InterPro
C 42 - 395 NGL View in InterPro
PK_C 410 - 528 1T5A A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
1ZJH A 409 - 527 NGL View in InterPro
3BJF A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
3BJT A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
3G2G A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
3GQY A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
3GR4 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
3H6O A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
3ME3 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
3SRD A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
3SRF A 409 - 527 NGL View in InterPro
B 409 - 527 NGL View in InterPro
C 409 - 527 NGL View in InterPro
D 409 - 527 NGL View in InterPro
E 409 - 527 NGL View in InterPro
F 409 - 527 NGL View in InterPro
G 409 - 527 NGL View in InterPro
H 409 - 527 NGL View in InterPro
3SRH A 409 - 527 NGL View in InterPro
B 409 - 527 NGL View in InterPro
C 409 - 527 NGL View in InterPro
D 409 - 527 NGL View in InterPro
3U2Z A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4B2D A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4FXF A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4FXJ A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4G1N A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4JPG A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4QG6 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4QG8 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4QG9 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4QGC A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4RPP A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4WJ8 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
4YJ5 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
5X0I A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
5X1V A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
5X1W A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6B6U A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
6GG3 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
E 410 - 528 NGL View in InterPro
F 410 - 528 NGL View in InterPro
G 410 - 528 NGL View in InterPro
H 410 - 528 NGL View in InterPro
I 410 - 528 NGL View in InterPro
J 410 - 528 NGL View in InterPro
K 410 - 528 NGL View in InterPro
L 410 - 528 NGL View in InterPro
6GG4 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6GG5 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6GG6 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
E 410 - 528 NGL View in InterPro
F 410 - 528 NGL View in InterPro
G 410 - 528 NGL View in InterPro
H 410 - 528 NGL View in InterPro
6JFB A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6NU1 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6NU5 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
6NUB A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
6TTF A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6TTH A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6TTI A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6TTQ A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6V74 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6V75 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6V76 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6WP3 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
6WP4 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6WP5 A 410 - 528 NGL View in InterPro
B 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
D 410 - 528 NGL View in InterPro
6WP6 A 410 - 528 NGL View in InterPro
C 410 - 528 NGL View in InterPro
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