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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IL2RB_HUMAN (P14784)

Summary

This is the summary of UniProt entry IL2RB_HUMAN (P14784).

Description: Interleukin-2 receptor subunit beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 551 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 26
low_complexity n/a 10 19
Pfam IL2RB_N1 32 123
transmembrane n/a 243 265
low_complexity n/a 305 315
disorder n/a 389 417
low_complexity n/a 427 449
disorder n/a 430 530
low_complexity n/a 468 483
disorder n/a 533 551

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P14784. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ
50
51
DGALQDTSCQ VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT
100
101
VDIVTLRVLC REGVRWRVMA IQDFKPFENL RLMAPISLQV VHVETHRCNI
150
151
SWEISQASHY FERHLEFEAR TLSPGHTWEE APLLTLKQKQ EWICLETLTP
200
201
DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT IPWLGHLLVG
250
251
LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV
300
301
QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS
350
351
SNHSLTSCFT NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP
400
401
TGSSPQPLQP LSGEDDAYCT FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA
450
451
GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP DLVDFQPPPE LVLREAGEEV
500
501
PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ ELQGQDPTHL
550
551
V                                                     
551
 

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Checksums:
CRC64:1A76FA1936BB7EE6
MD5:060ad22239ef6f04f6b10e824e2f8a9e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IL2RB_N1 32 - 123 2B5I B 6 - 97 NGL View in InterPro
2ERJ B 6 - 97 NGL View in InterPro
F 6 - 97 NGL View in InterPro
3QAZ c 6 - 97 NGL View in InterPro
E 6 - 97 NGL View in InterPro
f 6 - 97 NGL View in InterPro
H 6 - 97 NGL View in InterPro
i 6 - 97 NGL View in InterPro
K 6 - 97 NGL View in InterPro
T 6 - 97 NGL View in InterPro
W 6 - 97 NGL View in InterPro
Z 6 - 97 NGL View in InterPro
4GS7 B 6 - 97 NGL View in InterPro
5M5E B 6 - 97 NGL View in InterPro
33 - 123 3QAZ B 7 - 97 NGL View in InterPro
N 7 - 97 NGL View in InterPro
Q 7 - 97 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.