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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ANK1_HUMAN (P16157)

Summary

This is the summary of UniProt entry ANK1_HUMAN (P16157).

Description: Ankyrin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1881 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Ank 77 109
Pfam Ank 110 142
disorder n/a 188 195
Pfam Ank 205 235
Pfam Ank 238 270
disorder n/a 270 273
Pfam Ank 271 303
Pfam Ank 304 335
Pfam Ank 337 368
Pfam Ank 370 402
Pfam Ank 403 435
disorder n/a 434 441
Pfam Ank 438 468
low_complexity n/a 459 468
Pfam Ank 469 501
disorder n/a 472 474
low_complexity n/a 488 502
disorder n/a 500 507
Pfam Ank 502 534
Pfam Ank 535 567
disorder n/a 557 558
disorder n/a 561 563
disorder n/a 565 572
Pfam Ank 568 598
disorder n/a 600 603
Pfam Ank 601 633
Pfam Ank 634 666
disorder n/a 635 636
disorder n/a 638 639
disorder n/a 666 669
Pfam Ank 700 732
Pfam Ank 733 765
disorder n/a 736 737
disorder n/a 764 767
disorder n/a 809 813
disorder n/a 824 832
disorder n/a 840 841
disorder n/a 865 904
Pfam ZU5 915 1012
disorder n/a 929 933
disorder n/a 935 937
disorder n/a 956 960
disorder n/a 962 966
disorder n/a 970 971
coiled_coil n/a 1029 1049
low_complexity n/a 1038 1047
disorder n/a 1152 1162
Pfam UPA_2 1236 1365
disorder n/a 1326 1330
disorder n/a 1367 1375
disorder n/a 1397 1404
Pfam Death 1404 1486
disorder n/a 1485 1510
disorder n/a 1556 1558
disorder n/a 1563 1566
disorder n/a 1571 1575
disorder n/a 1580 1626
disorder n/a 1628 1821
low_complexity n/a 1772 1789
disorder n/a 1835 1881

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P16157. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH
50
51
LASKEGHVKM VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY
100
101
GANVNAQSQK GFTPLYMAAQ ENHLEVVKFL LENGANQNVA TEDGFTPLAV
150
151
ALQQGHENVV AHLINYGTKG KVRLPALHIA ARNDDTRTAA VLLQNDPNPD
200
201
VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI TPLHIASRRG
250
251
NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA
300
301
KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH
350
351
HRVAKVLLDK GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV
400
401
TESGLTPLHV ASFMGHLPIV KNLLQRGASP NVSNVKVETP LHMAARAGHT
450
451
EVAKYLLQNK AKVNAKAKDD QTPLHCAARI GHTNMVKLLL ENNANPNLAT
500
501
TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL HVAAKYGKVR
550
551
VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW
600
601
NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM
650
651
VALLLSKQAN GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM
700
701
GYTPLHVASH YGNIKLVKFL LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV
750
751
TLLLKNGASP NEVSSDGTTP LAIAKRLGYI SVTDVLKVVT DETSFVLVSD
800
801
KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE KELLDFVPKL
850
851
DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD
900
901
NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT
950
951
CRLVKPQKLS TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG
1000
1001
RGDRELVVLR SENGSVWKEH RSRYGESYLD QILNGMDEEL GSLEELEKKR
1050
1051
VCRIITTDFP LYFVIMSRLC QDYDTIGPEG GSLKSKLVPL VQATFPENAV
1100
1101
TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK FHRPIGLRIP
1150
1151
LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC
1200
1201
ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND
1250
1251
PREGRLRCYC MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN
1300
1301
LVPVKKAAQQ RSFHFQSFRE NRLAMPVKVR DSSREPGGSL SFLRKAMKYE
1350
1351
DTQHILCHLN ITMPPCAKGS GAEDRRRTPT PLALRYSILS ESTPGSLSGT
1400
1401
EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP NSLLEQSVAL
1450
1451
LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT
1500
1501
DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI
1550
1551
PLAATEHDTM LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW
1600
1601
KLEGALSEEP RGPELGSLEL VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL
1650
1651
PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ ARITHSPTVS QVTERSQDRL
1700
1701
QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE GLEPGGSQEY
1750
1751
EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN
1800
1801
EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT
1850
1851
VEGPLEDPSE LEVDIDYFMK HSKDHTSTPN P                    
1881
 

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Checksums:
CRC64:49466F6F915019EC
MD5:150527debf04e29bfadc67f89d1b5c5b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ank 405 - 435 1N11 A 405 - 435 NGL View in InterPro
438 - 468 1N11 A 438 - 468 NGL View in InterPro
469 - 501 1N11 A 469 - 501 NGL View in InterPro
502 - 534 1N11 A 502 - 534 NGL View in InterPro
535 - 567 1N11 A 535 - 567 NGL View in InterPro
568 - 598 1N11 A 568 - 598 NGL View in InterPro
601 - 633 1N11 A 601 - 633 NGL View in InterPro
634 - 666 1N11 A 634 - 666 NGL View in InterPro
700 - 732 1N11 A 700 - 732 NGL View in InterPro
733 - 765 1N11 A 733 - 765 NGL View in InterPro
Death 1404 - 1484 2YVI A 1405 - 1485 NGL View in InterPro
1404 - 1486 2YQF A 1404 - 1486 NGL View in InterPro
ZU5 915 - 1012 3F59 A 915 - 1012 NGL View in InterPro
B 915 - 1012 NGL View in InterPro
C 915 - 1012 NGL View in InterPro
D 915 - 1012 NGL View in InterPro
3KBT C 915 - 1012 NGL View in InterPro
D 915 - 1012 NGL View in InterPro
3KBU C 915 - 1012 NGL View in InterPro
D 915 - 1012 NGL View in InterPro
3UD1 A 915 - 1012 NGL View in InterPro
B 915 - 1012 NGL View in InterPro
C 915 - 1012 NGL View in InterPro
3UD2 A 915 - 1012 NGL View in InterPro
B 915 - 1012 NGL View in InterPro
C 915 - 1012 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.