Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FAS_MOUSE (P19096)

Summary

This is the summary of UniProt entry FAS_MOUSE (P19096).

Description: Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] reductase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Enoyl-[acyl-carrier-protein] reductase Acyl-[acyl-carrier-protein] hydrolase
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 2504 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam ketoacyl-synt 1 239
Pfam Ketoacyl-synt_C 243 360
disorder n/a 255 262
disorder n/a 293 296
disorder n/a 300 301
disorder n/a 324 329
disorder n/a 331 334
Pfam KAsynt_C_assoc 362 472
disorder n/a 406 408
low_complexity n/a 411 426
disorder n/a 414 419
disorder n/a 435 436
low_complexity n/a 472 485
Pfam Acyl_transf_1 493 810
Pfam PS-DH 853 1168
disorder n/a 861 862
disorder n/a 970 974
disorder n/a 979 983
low_complexity n/a 1035 1049
disorder n/a 1157 1165
low_complexity n/a 1175 1204
Pfam Methyltransf_12 1238 1337
disorder n/a 1274 1280
disorder n/a 1286 1295
disorder n/a 1477 1478
disorder n/a 1481 1482
Pfam ADH_zinc_N 1672 1809
Pfam KR 1878 2058
Pfam PP-binding 2119 2186
disorder n/a 2181 2204
low_complexity n/a 2185 2199
disorder n/a 2224 2228
Pfam Thioesterase 2235 2494
low_complexity n/a 2353 2360

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P19096. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEEVVIAGMS GKLPESENLQ EFWANLIGGV DMVTDDDRRW KAGLYGLPKR
50
51
SGKLKDLSKF DASFFGVHPK QAHTMDPQLR LLLEVSYEAI VDGGINPASL
100
101
RGTNTGVWVG VSGSEASEAL SRDPETLLGY SMVGCQRAMM ANRLSFFFDF
150
151
KGPSIALDTA CSSSLLALQN AYQAIRSGEC PAALVGGINL LLKPNTSVQF
200
201
MKLGMLSPDG TCRSFDDSGS GYCRSEAVVA VLLTKKSLAR RVYATILNAG
250
251
TNTDGSKEQG VTFPSGEVQE QLICSLYQPA GLAPESLEYI EAHGTGTKVG
300
301
DPQELNGITR SLCAFRQAPL LIGSTKSNMG HPEPASGLAA LTKVLLSLEH
350
351
GVWAPNLHFH NPNPEIPALL DGRLQVVDRP LPVRGGNVGI NSFGFGGSNV
400
401
HVILQPNTRQ APAPTAHAAL PHLLHASGRT LEAVQDLLEQ GRQHSQDLAF
450
451
VSMLNDIAAT PTAAMPFRGY TVLGVEGRVQ EVQQVSTNKR PLWFICSGMG
500
501
TQWRGMGLSL MRLDSFRESI LRSDEAVKPL GVKVSDLLLS TDERTFDDIV
550
551
HAFVSLTAIQ IALIDLLTSV GLKPDGIIGH SLGEVACGYA DGCLSQREAV
600
601
LAAYWRGQCI KDAHLPPGSM AAVGLSWEEC KQRCPAGVVP ACHNSEDTVT
650
651
ISGPQAAVNE FVEQLKQEGV FAKEVRTGGL AFHSYFMEGI APTLLQALKK
700
701
VIREPRPRSA RWLSTSIPEA QWQSSLARTS SAEYNVNNLV SPVLFQEALW
750
751
HIPEHAVVLE IAPHALLQAV LKRGVKSSCT IIPLMKRDHK DNLEFFLTNL
800
801
GKVHLTGINV NPNALFPPVE FPAPRGTPLI SPHIKWDHSQ TWDVPVAEDF
850
851
PNGSSSSSAT VYSIDASPES PDHYLVDHCI DGRVIFPGTG YLCLVWKTLA
900
901
RSLGLSLEET PVVFENVSFH QATILPKTGT VALEVRLLEA SHAFEVSDTG
950
951
NLIVSGKVYL WEDPNSKLFD HPEVPTPPES ASVSRLTQGE VYKELRLRGY
1000
1001
DYGPQFQGIC EATLEGEQGK LLWKDNWVTF MDTMLQVSIL GSSQQSLQLP
1050
1051
TRVTAIYIDP ATHRQKVYRL KEDTQVADVT TSRCLGITVS GGIHISRLQT
1100
1101
TATSRRQQEQ LVPTLEKFVF TPHMEAECLS ESTALQKELQ LCKGLARALQ
1150
1151
TKATQQGLKA AMLGQEDPPQ HGLPRLLAAA CQLQLNGNLQ LELGEALAQE
1200
1201
RLLLPEDPLI SGLLNSQALK ACVDTALENL STLKMKVAEV LAGEGHLYSR
1250
1251
IPALLNTQPM LQLEYTATDR HPQALKDVQT KLQQHDVAQG QWNPSDPAPS
1300
1301
SLGALDLLVC NCALATLGDP ALALDNMVAA LKEGGFLLVH TVLKGHALGE
1350
1351
TLACLPSEVQ PAPSLLSQEE WESLFSRKAL HLVGLKRSFY GTALFLCRRA
1400
1401
IPQEKPIFLS VEDTSFQWVD SLKSTLATSS SQPVWLTAMD CPTSGVVGLV
1450
1451
NCLRKEPGGH RIRCILLSNL SNTSHAPKLD PGSPELQQVL KHDLVMNVYR
1500
1501
DGAWGAFRHF QLEQDKPKEQ TAHAFVNVLT RGDLASIRWV SSPLKHTQPS
1550
1551
SSGAQLCTVY YASLNFRDIM LATGKLSPDA IPGKWASRDC MLGMEFSGRD
1600
1601
RCGRRVMGLV PAEGLATSVL LSSDFLWDVP SSWTLEEAAS VPVVYTTAYY
1650
1651
SLVVRGRIQR GETVLIHSGS GGVGQAAISI ALSLGCRVFT TVGSAEKRAY
1700
1701
LQARFPQLDD TSFANSRDTS FEQHVLLHTG GKGVDLVLNS LAEEKLQASV
1750
1751
RCLAQHGRFL EIGKFDLSNN HPLGMAIFLK NVTFHGILLD ALFEEANDSW
1800
1801
REVAALLKAG IRDGVVKPLK CTVFPKAQVE DAFRYMAQGK HIGKVLVQVR
1850
1851
EEEPEAVLPG AQPTLISAIS KTFCPAHKSY IITGGLGGFG LELARWLVLR
1900
1901
GAQRLVLTSR SGIRTGYQAK HIREWRRQGI QVLVSTSNVS SLEGARALIA
1950
1951
EATKLGPVGG VFNLAMVLRD AMLENQTPEL FQDVNKPKYN GTLNLDRATR
2000
2001
EACPELDYFV AFSSVSCGRG NAGQTNYGFA NSTMERICEQ RRHDGLPGLA
2050
2051
VQWGAIGDVG IVLEAMGTND TVIGGTLPQR ISSCMEVLDL FLNQPHAVLS
2100
2101
SFVLAEKKAV AHGDGDTQRD LVKAVAHILG IRDLAGINLD STLADLGLDS
2150
2151
LMGVEVRQIL EREHDLVLPM REVRQLTLRK LQEMSSKTDS ATDTTAPKSR
2200
2201
SDTSLKQNQL NLSTLLVNPE GPTLTQLNSV QSSERPLFLV HPIEGSTTVF
2250
2251
HSLAAKLSVP TYGLQCTQAA PLDSIPNLAA YYIDCIKQVQ PEGPYRIAGY
2300
2301
SFGACVAFEM CSQLQAQQGP APTHNNLFLF DGSHTYVLAY TQSYRAKMTP
2350
2351
GCEAEAEAEA LCFFIKQFLD VEHSKVLEAL LPLKSLEDRV AASVDLITKS
2400
2401
HHSLDRRELS FAAVSFYHKL RAADQYKPKA KYHGNVTLLR AKTGGTYGED
2450
2451
LGADYNLSQV CDGKVSVHII EGDHRTLLEG SGLESIINII HSSLAEPRVS
2500
2501
VREG                                                  
2504
 

Show the unformatted sequence.

Checksums:
CRC64:2B48068B9D370C6F
MD5:9dd9c357e3033b4d513340efd94d1abb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Acyl_transf_1 493 - 810 5MY0 A 493 - 810 Show 3D Structure View in InterPro
B 493 - 810 Show 3D Structure View in InterPro
C 493 - 810 Show 3D Structure View in InterPro
D 493 - 810 Show 3D Structure View in InterPro
5MY2 A 493 - 810 Show 3D Structure View in InterPro
B 493 - 810 Show 3D Structure View in InterPro
C 493 - 810 Show 3D Structure View in InterPro
D 493 - 810 Show 3D Structure View in InterPro
6ROP A 493 - 810 Show 3D Structure View in InterPro
B 493 - 810 Show 3D Structure View in InterPro
C 493 - 810 Show 3D Structure View in InterPro
D 493 - 810 Show 3D Structure View in InterPro
KAsynt_C_assoc 362 - 472 5MY0 A 362 - 472 Show 3D Structure View in InterPro
B 362 - 472 Show 3D Structure View in InterPro
C 362 - 472 Show 3D Structure View in InterPro
D 362 - 472 Show 3D Structure View in InterPro
5MY2 A 362 - 472 Show 3D Structure View in InterPro
B 362 - 472 Show 3D Structure View in InterPro
C 362 - 472 Show 3D Structure View in InterPro
D 362 - 472 Show 3D Structure View in InterPro
6ROP A 362 - 472 Show 3D Structure View in InterPro
B 362 - 472 Show 3D Structure View in InterPro
C 362 - 472 Show 3D Structure View in InterPro
D 362 - 472 Show 3D Structure View in InterPro
ketoacyl-synt 2 - 239 5MY0 A 2 - 239 Show 3D Structure View in InterPro
B 2 - 239 Show 3D Structure View in InterPro
C 2 - 239 Show 3D Structure View in InterPro
D 2 - 239 Show 3D Structure View in InterPro
5MY2 A 2 - 239 Show 3D Structure View in InterPro
B 2 - 239 Show 3D Structure View in InterPro
C 2 - 239 Show 3D Structure View in InterPro
D 2 - 239 Show 3D Structure View in InterPro
6ROP A 2 - 239 Show 3D Structure View in InterPro
B 2 - 239 Show 3D Structure View in InterPro
C 2 - 239 Show 3D Structure View in InterPro
D 2 - 239 Show 3D Structure View in InterPro
Ketoacyl-synt_C 243 - 360 5MY0 A 243 - 360 Show 3D Structure View in InterPro
B 243 - 360 Show 3D Structure View in InterPro
C 243 - 360 Show 3D Structure View in InterPro
D 243 - 360 Show 3D Structure View in InterPro
5MY2 A 243 - 360 Show 3D Structure View in InterPro
B 243 - 360 Show 3D Structure View in InterPro
C 243 - 360 Show 3D Structure View in InterPro
D 243 - 360 Show 3D Structure View in InterPro
6ROP A 243 - 360 Show 3D Structure View in InterPro
B 243 - 360 Show 3D Structure View in InterPro
C 243 - 360 Show 3D Structure View in InterPro
D 243 - 360 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;