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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SL9A1_HUMAN (P19634)

Summary

This is the summary of UniProt entry SL9A1_HUMAN (P19634).

Description: Sodium/hydrogen exchanger 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 815 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
transmembrane n/a 15 32
low_complexity n/a 19 32
disorder n/a 43 45
disorder n/a 48 79
Pfam Na_H_Exchanger 105 505
transmembrane n/a 105 122
transmembrane n/a 128 148
low_complexity n/a 134 150
transmembrane n/a 160 177
low_complexity n/a 161 171
transmembrane n/a 189 216
transmembrane n/a 228 246
transmembrane n/a 258 277
transmembrane n/a 289 319
low_complexity n/a 292 314
transmembrane n/a 339 362
transmembrane n/a 383 405
transmembrane n/a 411 437
transmembrane n/a 449 468
transmembrane n/a 480 503
Pfam NEXCaM_BD 599 700
disorder n/a 600 602
disorder n/a 605 608
disorder n/a 615 622
coiled_coil n/a 625 652
disorder n/a 631 637
disorder n/a 646 647
disorder n/a 650 651
disorder n/a 678 815
low_complexity n/a 753 759
low_complexity n/a 798 812

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P19634. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVLRSGICGL SPHRIFPSLL VVVALVGLLP VLRSHGLQLS PTASTIRSSE
50
51
PPRERSIGDV TTAPPEVTPE SRPVNHSVTD HGMKPRKAFP VLGIDYTHVR
100
101
TPFEISLWIL LACLMKIGFH VIPTISSIVP ESCLLIVVGL LVGGLIKGVG
150
151
ETPPFLQSDV FFLFLLPPII LDAGYFLPLR QFTENLGTIL IFAVVGTLWN
200
201
AFFLGGLMYA VCLVGGEQIN NIGLLDNLLF GSIISAVDPV AVLAVFEEIH
250
251
INELLHILVF GESLLNDAVT VVLYHLFEEF ANYEHVGIVD IFLGFLSFFV
300
301
VALGGVLVGV VYGVIAAFTS RFTSHIRVIE PLFVFLYSYM AYLSAELFHL
350
351
SGIMALIASG VVMRPYVEAN ISHKSHTTIK YFLKMWSSVS ETLIFIFLGV
400
401
STVAGSHHWN WTFVISTLLF CLIARVLGVL GLTWFINKFR IVKLTPKDQF
450
451
IIAYGGLRGA IAFSLGYLLD KKHFPMCDLF LTAIITVIFF TVFVQGMTIR
500
501
PLVDLLAVKK KQETKRSINE EIHTQFLDHL LTGIEDICGH YGHHHWKDKL
550
551
NRFNKKYVKK CLIAGERSKE PQLIAFYHKM EMKQAIELVE SGGMGKIPSA
600
601
VSTVSMQNIH PKSLPSERIL PALSKDKEEE IRKILRNNLQ KTRQRLRSYN
650
651
RHTLVADPYE EAWNQMLLRR QKARQLEQKI NNYLTVPAHK LDSPTMSRAR
700
701
IGSDPLAYEP KEDLPVITID PASPQSPESV DLVNEELKGK VLGLSRDPAK
750
751
VAEEDEDDDG GIMMRSKETS SPGTDDVFTP APSDSPSSQR IQRCLSDPGP
800
801
HPEPGEGEPF FPKGQ                                      
815
 

Show the unformatted sequence.

Checksums:
CRC64:02EC748C79DF6526
MD5:bef896743d3ab81b02e2230c0ab38ca2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Na_H_Exchanger 155 - 180 1Y4E A 155 - 180 NGL View in InterPro
226 - 250 2L0E A 226 - 250 NGL View in InterPro
226 - 274 2MDF A 226 - 274 NGL View in InterPro
431 - 443 6BJF A 1 - 13 NGL View in InterPro
447 - 472 2KBV A 447 - 472 NGL View in InterPro
503 - 505 2E30 B 503 - 505 NGL View in InterPro
NEXCaM_BD 622 - 685 2YGG A 622 - 685 NGL View in InterPro
681 - 688 6NUC C 681 - 688 NGL View in InterPro
6NUF C 681 - 688 NGL View in InterPro
682 - 688 6NUU C 682 - 688 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;