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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TYPH_HUMAN (P19971)

Summary

This is the summary of UniProt entry TYPH_HUMAN (P19971).

Description: Thymidine phosphorylase EC=2.4.2.4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 482 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 45
low_complexity n/a 6 16
Pfam Glycos_trans_3N 37 99
disorder n/a 106 109
Pfam Glycos_transf_3 109 340
low_complexity n/a 320 339
disorder n/a 368 379
Pfam PYNP_C 388 461
disorder n/a 439 446
disorder n/a 451 453
disorder n/a 478 480

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P19971. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS
50
51
EADIRGFVAA VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ
100
101
QLEWPEAWRQ QLVDKHSTGG VGDKVSLVLA PALAACGCKV PMISGRGLGH
150
151
TGGTLDKLES IPGFNVIQSP EQMQVLLDQA GCCIVGQSEQ LVPADGILYA
200
201
ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA VFPNQEQARE
250
251
LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP
300
301
DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ
350
351
GVDPGLARAL CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV
400
401
LHELGAGRSR AGEPLRLGVG AELLVDVGQR LRRGTPWLRV HRDGPALSGP
450
451
QSRALQEALV LSDRAPFAAP SPFAELVLPP QQ                   
482
 

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Checksums:
CRC64:0652FA0B8F3BDE28
MD5:b239939300c6c3126f9d9ebd53c4aa74

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Glycos_trans_3N 37 - 99 1UOU A 37 - 99 Show 3D Structure View in InterPro
2J0F A 37 - 99 Show 3D Structure View in InterPro
B 37 - 99 Show 3D Structure View in InterPro
C 37 - 99 Show 3D Structure View in InterPro
D 37 - 99 Show 3D Structure View in InterPro
2WK5 A 37 - 99 Show 3D Structure View in InterPro
B 37 - 99 Show 3D Structure View in InterPro
C 37 - 99 Show 3D Structure View in InterPro
D 37 - 99 Show 3D Structure View in InterPro
2WK6 A 37 - 99 Show 3D Structure View in InterPro
B 37 - 99 Show 3D Structure View in InterPro
Glycos_transf_3 109 - 340 1UOU A 109 - 340 Show 3D Structure View in InterPro
2J0F A 109 - 340 Show 3D Structure View in InterPro
B 109 - 340 Show 3D Structure View in InterPro
C 109 - 340 Show 3D Structure View in InterPro
D 109 - 340 Show 3D Structure View in InterPro
2WK5 A 109 - 340 Show 3D Structure View in InterPro
B 109 - 340 Show 3D Structure View in InterPro
C 109 - 340 Show 3D Structure View in InterPro
D 109 - 340 Show 3D Structure View in InterPro
2WK6 A 109 - 340 Show 3D Structure View in InterPro
B 109 - 340 Show 3D Structure View in InterPro
PYNP_C 388 - 461 1UOU A 388 - 461 Show 3D Structure View in InterPro
2J0F A 388 - 461 Show 3D Structure View in InterPro
B 388 - 461 Show 3D Structure View in InterPro
C 388 - 461 Show 3D Structure View in InterPro
D 388 - 461 Show 3D Structure View in InterPro
2WK5 A 388 - 461 Show 3D Structure View in InterPro
B 388 - 461 Show 3D Structure View in InterPro
C 388 - 461 Show 3D Structure View in InterPro
D 388 - 461 Show 3D Structure View in InterPro
2WK6 A 388 - 461 Show 3D Structure View in InterPro
B 388 - 461 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;