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29  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FGFR4_HUMAN (P22455)

Summary

This is the summary of UniProt entry FGFR4_HUMAN (P22455).

Description: Fibroblast growth factor receptor 4 EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 802 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 21
low_complexity n/a 3 22
low_complexity n/a 19 31
disorder n/a 119 150
disorder n/a 153 156
Pfam I-set 154 241
Pfam Ig_3 249 337
transmembrane n/a 370 390
low_complexity n/a 372 390
low_complexity n/a 419 442
low_complexity n/a 438 452
Pfam PK_Tyr_Ser-Thr 467 743
disorder n/a 498 502
disorder n/a 564 578
low_complexity n/a 765 783
disorder n/a 775 777
low_complexity n/a 786 799

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P22455. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG
50
51
QPVRLCCGRA ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL
100
101
CLARGSMIVL QNLTLITGDS LTSSNDDEDP KSHRDPSNRH SYPQQAPYWT
150
151
HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP TIRWLKDGQA FHGENRIGGI
200
201
RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD VLERSPHRPI
250
251
LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP
300
301
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV
350
351
LPEEDPTWTA AAPEARYTDI ILYASGSLAL AVLLLLAGLY RGQALHGRHP
400
401
RPPATVQKLS RFPLARQFSL ESGSSGKSSS SLVRGVRLSS SGPALLAGLV
450
451
SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ VVRAEAFGMD PARPDQASTV
500
501
AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC TQEGPLYVIV
550
551
ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPVLV SCAYQVARGM
600
601
QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR
650
651
LPVKWMAPEA LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS
700
701
LLREGHRMDR PPHCPPELYG LMRECWHAAP SQRPTFKQLV EALDKVLLAV
750
751
SEEYLDLRLT FGPYSPSGGD ASSTCSSSDS VFSHDPLPLG SSSFPFGSGV
800
801
QT                                                    
802
 

Show the unformatted sequence.

Checksums:
CRC64:B22B259831BB889F
MD5:0c799cd8eb4a963b013291894bf69e69

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
I-set 154 - 241 6J6Y A 161 - 248 NGL View in InterPro
D 161 - 248 NGL View in InterPro
PK_Tyr_Ser-Thr 467 - 743 4QQ5 A 472 - 748 NGL View in InterPro
4QQC A 467 - 743 NGL View in InterPro
4QQJ A 467 - 743 NGL View in InterPro
4QQT A 467 - 743 NGL View in InterPro
4QRC A 467 - 743 NGL View in InterPro
4R6V A 467 - 743 NGL View in InterPro
4TYE A 467 - 743 NGL View in InterPro
4TYG A 467 - 743 NGL View in InterPro
4TYI A 467 - 743 NGL View in InterPro
4TYJ A 467 - 743 NGL View in InterPro
4UXQ A 467 - 743 NGL View in InterPro
4XCU A 467 - 743 NGL View in InterPro
5JKG A 467 - 743 NGL View in InterPro
5NUD A 467 - 743 NGL View in InterPro
B 467 - 743 NGL View in InterPro
5NWZ A 467 - 743 NGL View in InterPro
B 467 - 743 NGL View in InterPro
5XFF A 467 - 743 NGL View in InterPro
5XFJ A 467 - 743 NGL View in InterPro
6IUO A 467 - 743 NGL View in InterPro
6IUP A 467 - 743 NGL View in InterPro
6JPE A 467 - 743 NGL View in InterPro
6JPJ A 467 - 743 NGL View in InterPro
6NVG A 467 - 734 NGL View in InterPro
6NVH A 467 - 734 NGL View in InterPro
6NVI A 467 - 734 NGL View in InterPro
6NVJ A 467 - 734 NGL View in InterPro
6NVK A 467 - 734 NGL View in InterPro
6V9C A 467 - 743 NGL View in InterPro
6YI8 A 467 - 743 NGL View in InterPro
B 467 - 743 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;