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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: XDH_RAT (P22985)

Summary

This is the summary of UniProt entry XDH_RAT (P22985).

Description: Xanthine dehydrogenase/oxidase Xanthine dehydrogenase Xanthine oxidase
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 1331 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Fer2 8 78
low_complexity n/a 30 52
Pfam Fer2_2 87 160
low_complexity n/a 166 181
disorder n/a 181 182
disorder n/a 198 199
disorder n/a 201 203
disorder n/a 211 215
Pfam FAD_binding_5 227 411
Pfam CO_deh_flav_C 418 522
disorder n/a 559 565
disorder n/a 570 579
Pfam Ald_Xan_dh_C 587 693
Pfam MoCoBD_1 698 946
Pfam MoCoBD_2 970 1236
disorder n/a 1065 1079
low_complexity n/a 1066 1079
low_complexity n/a 1078 1083

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P22985. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTADELVFFV NGKKVVEKNA DPETTLLVYL RRKLGLCGTK LGCGEGGCGA
50
51
CTVMISKYDR LQNKIVHFSV NACLAPICSL HHVAVTTVEG IGNTQKLHPV
100
101
QERIARSHGS QCGFCTPGIV MSMYTLLRNQ PEPTVEEIEN AFQGNLCRCT
150
151
GYRPILQGFR TFAKDGGCCG GSGNNPNCCM NQTKDQTVSL SPSLFNPEDF
200
201
KPLDPTQEPI FPPELLRLKD TPQKKLRFEG ERVTWIQAST MEELLDLKAQ
250
251
HPDAKLVVGN TEIGIEMKFK NMLFPLIVCP AWIPELNSVV HGPEGISFGA
300
301
SCPLSLVESV LAEEIAKLPE QKTEVFRGVM EQLRWFAGKQ VKSVASIGGN
350
351
IITASPISDL NPVFMASGAK LTLVSRGTRR TVRMDHTFFP GYRKTLLRPE
400
401
EILLSIEIPY SKEGEFFSAF KQASRREDDI AKVTSGMRVL FKPGTIEVQE
450
451
LSLCFGGMAD RTISALKTTP KQLSKSWNEE LLQSVCAGLA EELQLAPDAP
500
501
GGMVEFRRTL TLSFFFKFYL TVLQKLGRAD LEDMCGKLDP TFASATLLFQ
550
551
KDPPANVQLF QEVPKDQSEE DMVGRPLPHL AANMQASGEA VYCDDIPRYE
600
601
NELSLRLVTS TRAHAKITSI DTSEAKKVPG FVCFLTAEDV PNSNATGLFN
650
651
DETVFAKDEV TCVGHIIGAV VADTPEHAQR AARGVKITYE DLPAIITIQD
700
701
AINNNSFYGS EIKIEKGDLK KGFSEADNVV SGELYIGGQE HFYLETNCTI
750
751
AVPKGEAGEM ELFVSTQNTM KTQSFVAKML GVPDNRIVVR VKRMGGGFGG
800
801
KETRSTVVST ALALAAHKTG RPVRCMLDRD EDMLITGGRH PFLAKYKVGF
850
851
MKTGTVVALE VAHFSNGGNT EDLSRSIMER ALFHMDNAYK IPNIRGTGRI
900
901
CKTNLPSNTA FRGFGGPQGM LIAEYWMSEV AITCGLPAEE VRRKNMYKEG
950
951
DLTHFNQKLE GFTLPRCWDE CIASSQYLAR KREVEKFNRE NCWKKRGLCI
1000
1001
IPTKFGISFT LPFLNQGGAL VHVYTDGSVL LTHGGTEMGQ GLHTKMVQVA
1050
1051
SRALKIPTSK IHISETSTNT VPNTSPTAAS ASADLNGQGV YEACQTILKR
1100
1101
LEPFKKKKPT GPWEAWVMDA YTSAVSLSAT GFYKTPNLGY SFETNSGNPF
1150
1151
HYFSYGVACS EVEIDCLTGD HKNLRTDIVM DVGSSLNPAI DIGQVEGAFV
1200
1201
QGLGLFTMEE LHYSPEGSLH TRGPSTYKIP AFGSIPIEFR VSLLRDCPNK
1250
1251
RAIYASKAVG EPPLFLASSI FFAIKDAIRA ARAQHGDNAK QLFQLDSPAT
1300
1301
PEKIRNACVD QFTTLCVTGV PENCKSWSVR I                    
1331
 

Show the unformatted sequence.

Checksums:
CRC64:BF2586A9C63A0B2C
MD5:74433224458314f98ce9a43b9fdadfa5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ald_Xan_dh_C 587 - 693 1WYG A 587 - 693 Show 3D Structure View in InterPro
2E3T A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
3AN1 A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
4YRW A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
4YSW A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
4YTY A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
4YTZ A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
6A7X A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
6ABU A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
6AC1 A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
6AC4 A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
6AD4 A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
6ADJ A 587 - 693 Show 3D Structure View in InterPro
B 587 - 693 Show 3D Structure View in InterPro
6AJU A 587 - 693 Show 3D Structure View in InterPro
F 587 - 693 Show 3D Structure View in InterPro
CO_deh_flav_C 418 - 522 1WYG A 418 - 522 Show 3D Structure View in InterPro
2E3T A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
3AN1 A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
4YRW A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
4YSW A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
4YTY A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
4YTZ A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
6A7X A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
6ABU A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
6AC1 A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
6AC4 A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
6AD4 A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
6ADJ A 418 - 522 Show 3D Structure View in InterPro
B 418 - 522 Show 3D Structure View in InterPro
6AJU A 418 - 522 Show 3D Structure View in InterPro
F 418 - 522 Show 3D Structure View in InterPro
FAD_binding_5 227 - 411 1WYG A 227 - 411 Show 3D Structure View in InterPro
2E3T A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
3AN1 A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
4YRW A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
4YSW A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
4YTY A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
4YTZ A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
6A7X A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
6ABU A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
6AC1 A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
6AC4 A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
6AD4 A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
6ADJ A 227 - 411 Show 3D Structure View in InterPro
B 227 - 411 Show 3D Structure View in InterPro
6AJU A 227 - 411 Show 3D Structure View in InterPro
F 227 - 411 Show 3D Structure View in InterPro
Fer2 8 - 78 1WYG A 8 - 78 Show 3D Structure View in InterPro
2E3T A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
3AN1 A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
4YRW A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
4YSW A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
4YTY A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
4YTZ A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
6A7X A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
6ABU A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
6AC1 A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
6AC4 A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
6AD4 A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
6ADJ A 8 - 78 Show 3D Structure View in InterPro
B 8 - 78 Show 3D Structure View in InterPro
6AJU A 8 - 78 Show 3D Structure View in InterPro
F 8 - 78 Show 3D Structure View in InterPro
Fer2_2 87 - 160 1WYG A 87 - 160 Show 3D Structure View in InterPro
2E3T A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
3AN1 A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
4YRW A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
4YSW A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
4YTY A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
4YTZ A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
6A7X A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
6ABU A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
6AC1 A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
6AC4 A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
6AD4 A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
6ADJ A 87 - 160 Show 3D Structure View in InterPro
B 87 - 160 Show 3D Structure View in InterPro
6AJU A 87 - 160 Show 3D Structure View in InterPro
F 87 - 160 Show 3D Structure View in InterPro
MoCoBD_1 698 - 946 1WYG A 698 - 946 Show 3D Structure View in InterPro
2E3T A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
3AN1 A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
4YRW A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
4YSW A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
4YTY A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
4YTZ A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
6A7X A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
6ABU A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
6AC1 A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
6AC4 A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
6AD4 A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
6ADJ A 698 - 946 Show 3D Structure View in InterPro
B 698 - 946 Show 3D Structure View in InterPro
6AJU A 698 - 946 Show 3D Structure View in InterPro
F 698 - 946 Show 3D Structure View in InterPro
MoCoBD_2 970 - 1236 1WYG A 970 - 1236 Show 3D Structure View in InterPro
2E3T A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
3AN1 A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
4YRW A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
4YSW A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
4YTY A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
4YTZ A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
6A7X A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
6ABU A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
6AC1 A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
6AC4 A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
6AD4 A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
6ADJ A 970 - 1236 Show 3D Structure View in InterPro
B 970 - 1236 Show 3D Structure View in InterPro
6AJU A 970 - 1236 Show 3D Structure View in InterPro
F 970 - 1236 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;