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48  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: JAK1_HUMAN (P23458)

Summary

This is the summary of UniProt entry JAK1_HUMAN (P23458).

Description: Tyrosine-protein kinase JAK1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1154 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam FERM_F1 36 129
disorder n/a 124 134
disorder n/a 137 141
Pfam FERM_F2 147 277
disorder n/a 181 182
Pfam Jak1_Phl 284 421
coiled_coil n/a 334 358
low_complexity n/a 335 358
disorder n/a 336 339
disorder n/a 342 354
Pfam PK_Tyr_Ser-Thr 583 845
disorder n/a 852 862
Pfam PK_Tyr_Ser-Thr 875 1149
disorder n/a 902 910
low_complexity n/a 970 982

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23458. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL
50
51
GSGEYTAEEL CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK
100
101
MSLRLHYRMR FYFTNWHGTN DNEQSVWRHS PKKQKNGYEK KKIPDATPLL
150
151
DASSLEYLFA QGQYDLVKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
200
201
AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE
250
251
FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN
300
301
WFHSNDGGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH
350
351
KKDEEKNKIR EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE
400
401
EALSFVSLVD GYFRLTADAH HYLCTDVAPP LIVHNIQNGC HGPICTEYAI
450
451
NKLRQEGSEE GMYVLRWSCT DFDNILMTVT CFEKSEQVQG AQKQFKNFQI
500
501
EVQKGRYSLH GSDRSFPSLG DLMSHLKKQI LRTDNISFML KRCCQPKPRE
550
551
ISNLLVATKK AQEWQPVYPM SQLSFDRILK KDLVQGEHLG RGTRTHIYSG
600
601
TLMDYKDDEG TSEEKKIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI
650
651
VYLYGVCVRD VENIMVEEFV EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS
700
701
ALSYLEDKDL VHGNVCTKNL LLAREGIDSE CGPFIKLSDP GIPITVLSRQ
750
751
ECIERIPWIA PECVEDSKNL SVAADKWSFG TTLWEICYNG EIPLKDKTLI
800
801
EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA IMRDINKLEE
850
851
QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN
900
901
TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN
950
951
GIKLIMEFLP SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV
1000
1001
HRDLAARNVL VESEHQVKIG DFGLTKAIET DKEYYTVKDD RDSPVFWYAP
1050
1051
ECLMQSKFYI ASDVWSFGVT LHELLTYCDS DSSPMALFLK MIGPTHGQMT
1100
1101
VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT SFQNLIEGFE
1150
1151
ALLK                                                  
1154
 

Show the unformatted sequence.

Checksums:
CRC64:A2C4BE27851ACABB
MD5:933420e3eac5be8b1760cde731133e4a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FERM_F1 36 - 129 5IXD A 36 - 129 NGL View in InterPro
5IXI A 36 - 129 NGL View in InterPro
5L04 A 36 - 129 NGL View in InterPro
FERM_F2 147 - 277 5IXD A 147 - 277 NGL View in InterPro
5IXI A 147 - 277 NGL View in InterPro
5L04 A 147 - 277 NGL View in InterPro
Jak1_Phl 284 - 421 5IXD A 284 - 421 NGL View in InterPro
5IXI A 284 - 421 NGL View in InterPro
5L04 A 284 - 421 NGL View in InterPro
PK_Tyr_Ser-Thr 583 - 845 4L00 A 583 - 845 NGL View in InterPro
B 583 - 845 NGL View in InterPro
4L01 A 583 - 845 NGL View in InterPro
B 583 - 845 NGL View in InterPro
875 - 1149 3EYG A 875 - 1149 NGL View in InterPro
3EYH A 875 - 1149 NGL View in InterPro
4E4L A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
D 875 - 1149 NGL View in InterPro
E 875 - 1149 NGL View in InterPro
4E4N A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
4E5W A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
4EHZ A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
C 875 - 1149 NGL View in InterPro
D 875 - 1149 NGL View in InterPro
4EI4 A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
4FK6 A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
4I5C A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
4IVB A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
4IVC A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
4IVD A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
4K6Z A 875 - 1149 NGL View in InterPro
4K77 A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
5E1E A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
5HX8 A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
5KHW A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
5KHX A 875 - 1149 NGL View in InterPro
5WO4 A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6AAH A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6BBU A 875 - 1149 NGL View in InterPro
6C7Y A 875 - 1149 NGL View in InterPro
6DBN A 875 - 1149 NGL View in InterPro
6ELR A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6GGH A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6HZU A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6N77 A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6N78 A 875 - 1149 NGL View in InterPro
6N79 A 875 - 1149 NGL View in InterPro
6N7A A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6N7B A 875 - 1149 NGL View in InterPro
6N7C A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6N7D A 875 - 1149 NGL View in InterPro
6RSB A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6RSC A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6RSD A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6RSE A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6RSH A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6SM8 A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6SMB A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6TPE A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6TPF A 875 - 1149 NGL View in InterPro
B 875 - 1149 NGL View in InterPro
6W8L A 875 - 1149 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.