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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IBP5_HUMAN (P24593)

Summary

This is the summary of UniProt entry IBP5_HUMAN (P24593).

Description: Insulin-like growth factor-binding protein 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 272 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 20
low_complexity n/a 3 18
Pfam IGFBP 27 80
disorder n/a 111 139
disorder n/a 143 153
disorder n/a 158 204
Pfam Thyroglobulin_1 192 263

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P24593. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE
50
51
PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC
100
101
LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE
150
151
AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL
200
201
QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK
250
251
LPGMEYVDGD FQCHTFDSSN VE                              
272
 

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Checksums:
CRC64:0A7AD37C6EEA3A81
MD5:bc51f49421aae91a9fd48b577d1f47c5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IGFBP 59 - 80 1H59 B 39 - 60 NGL View in InterPro
60 - 80 1BOE A 13 - 33 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.