Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
31  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: U2AF2_HUMAN (P26368)

Summary

This is the summary of UniProt entry U2AF2_HUMAN (P26368).

Description: Splicing factor U2AF 65 kDa subunit
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 475 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 97
coiled_coil n/a 4 24
low_complexity n/a 23 62
disorder n/a 99 141
disorder n/a 143 144
Pfam RRM_1 151 225
disorder n/a 230 233
low_complexity n/a 242 257
Pfam RRM_1 261 331
low_complexity n/a 384 405
Pfam RRM_1 399 460

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P26368. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSDFDEFERQ LNENKQERDK ENRHRKRSHS RSRSRDRKRR SRSRDRRNRD
50
51
QRSASRDRRR RSKPLTRGAK EEHGGLIRSP RHEKKKKVRK YWDVPPPGFE
100
101
HITPMQYKAM QAAGQIPATA LLPTMTPDGL AVTPTPVPVV GSQMTRQARR
150
151
LYVGNIPFGI TEEAMMDFFN AQMRLGGLTQ APGNPVLAVQ INQDKNFAFL
200
201
EFRSVDETTQ AMAFDGIIFQ GQSLKIRRPH DYQPLPGMSE NPSVYVPGVV
250
251
STVVPDSAHK LFIGGLPNYL NDDQVKELLT SFGPLKAFNL VKDSATGLSK
300
301
GYAFCEYVDI NVTDQAIAGL NGMQLGDKKL LVQRASVGAK NATLVSPPST
350
351
INQTPVTLQV PGLMSSQVQM GGHPTEVLCL MNMVLPEELL DDEEYEEIVE
400
401
DVRDECSKYG LVKSIEIPRP VDGVEVPGCG KIFVEFTSVF DCQKAMQGLT
450
451
GRKFANRVVV TKYCDPDSYH RRDFW                           
475
 

Show the unformatted sequence.

Checksums:
CRC64:26AD271CD8FC6211
MD5:f276ac8946ce3fd4d170d3ef19dc29a0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RRM_1 151 - 225 1U2F A 4 - 78 NGL View in InterPro
2G4B A 151 - 225 NGL View in InterPro
2HZC A 151 - 225 NGL View in InterPro
2YH0 A 151 - 225 NGL View in InterPro
2YH1 A 151 - 225 NGL View in InterPro
3VAF A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
3VAG A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
3VAH A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
3VAI A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
3VAJ A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
3VAK A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
3VAL A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
D 151 - 225 NGL View in InterPro
I 151 - 225 NGL View in InterPro
3VAM A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
4TU7 A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
4TU8 A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
4TU9 A 151 - 225 NGL View in InterPro
B 151 - 225 NGL View in InterPro
5EV1 A 151 - 225 NGL View in InterPro
5EV2 A 151 - 225 NGL View in InterPro
5EV3 A 151 - 225 NGL View in InterPro
5EV4 A 151 - 225 NGL View in InterPro
5W0G A 151 - 225 NGL View in InterPro
6TR0 A 151 - 225 NGL View in InterPro
6XLV A 151 - 225 NGL View in InterPro
6XLW A 151 - 225 NGL View in InterPro
6XLX A 151 - 225 NGL View in InterPro
261 - 331 2G4B A 261 - 331 NGL View in InterPro
2U2F A 4 - 74 NGL View in InterPro
2YH0 A 261 - 331 NGL View in InterPro
2YH1 A 261 - 331 NGL View in InterPro
3VAF A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
3VAG A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
3VAH A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
3VAI A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
3VAJ A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
3VAK A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
3VAL A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
D 261 - 331 NGL View in InterPro
I 261 - 331 NGL View in InterPro
3VAM A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
4TU7 A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
4TU8 A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
4TU9 A 261 - 331 NGL View in InterPro
B 261 - 331 NGL View in InterPro
5EV1 A 261 - 331 NGL View in InterPro
5EV2 A 261 - 331 NGL View in InterPro
5EV3 A 261 - 331 NGL View in InterPro
5EV4 A 261 - 331 NGL View in InterPro
5W0H A 261 - 331 NGL View in InterPro
6TR0 A 261 - 331 NGL View in InterPro
6XLV A 261 - 331 NGL View in InterPro
6XLW A 261 - 331 NGL View in InterPro
6XLX A 261 - 331 NGL View in InterPro
399 - 460 1O0P A 399 - 460 NGL View in InterPro
1OPI A 399 - 460 NGL View in InterPro
2M0G B 399 - 460 NGL View in InterPro
4FXW A 399 - 460 NGL View in InterPro
C 399 - 460 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;