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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DUS1_HUMAN (P28562)

Summary

This is the summary of UniProt entry DUS1_HUMAN (P28562).

Description: Dual specificity protein phosphatase 1 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 367 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Rhodanese 9 131
low_complexity n/a 102 116
Pfam DSPc 181 311

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P28562. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST
50
51
IVRRRAKGAM GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG
100
101
TLALAAGALC REARAAQVFF LKGGYEAFSA SCPELCSKQS TPMGLSLPLS
150
151
TSVPDSAESG CSSCSTPLYD QGGPVEILPF LYLGSAYHAS RKDMLDALGI
200
201
TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA IDFIDSIKNA
250
251
GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS
300
301
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST
350
351
NSALSYLQSP ITTSPSC                                    
367
 

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Checksums:
CRC64:11BD1D39A9FCD51F
MD5:658d5649faf60f03219240ea2e68c930

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DSPc 181 - 311 6APX A 1181 - 1311 NGL View in InterPro
6D65 A 381 - 511 NGL View in InterPro
C 381 - 511 NGL View in InterPro
6D66 A 381 - 511 NGL View in InterPro
6D67 A 381 - 511 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.