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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ARI4A_HUMAN (P29374)

Summary

This is the summary of UniProt entry ARI4A_HUMAN (P29374).

Description: AT-rich interactive domain-containing protein 4A
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1257 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 28 43
disorder n/a 62 63
disorder n/a 118 121
disorder n/a 131 138
disorder n/a 142 169
low_complexity n/a 152 167
Pfam RBB1NT 170 262
disorder n/a 235 236
disorder n/a 240 241
low_complexity n/a 267 281
disorder n/a 270 310
low_complexity n/a 278 313
coiled_coil n/a 288 308
Pfam ARID 311 397
low_complexity n/a 410 422
disorder n/a 411 580
coiled_coil n/a 414 437
low_complexity n/a 418 430
coiled_coil n/a 470 490
low_complexity n/a 480 499
low_complexity n/a 494 506
low_complexity n/a 526 558
low_complexity n/a 560 571
Pfam Tudor-knot 574 630
disorder n/a 591 596
disorder n/a 633 761
low_complexity n/a 638 666
coiled_coil n/a 639 662
low_complexity n/a 689 704
coiled_coil n/a 710 730
disorder n/a 769 800
low_complexity n/a 775 788
disorder n/a 810 811
disorder n/a 813 837
disorder n/a 841 845
disorder n/a 861 918
disorder n/a 925 930
disorder n/a 932 947
disorder n/a 949 955
disorder n/a 957 960
low_complexity n/a 961 972
disorder n/a 962 966
disorder n/a 968 994
disorder n/a 999 1048
disorder n/a 1052 1176
disorder n/a 1183 1188
coiled_coil n/a 1186 1220
disorder n/a 1209 1257
low_complexity n/a 1211 1222
low_complexity n/a 1225 1248

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P29374. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKAADEPAYL TVGTDVSAKY RGAFCEAKIK TVKRLVKVKV LLKQDNTTQL
50
51
VQDDQVKGPL RVGAIVETRT SDGSFQEAII SKLTDASWYT VVFDDGDERT
100
101
LRRTSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIAKKT NRGRRSSLPV
150
151
TEDEKEEESS EEEDEDKRRL NDELLGKVVS VVSATERTEW YPALVISPSC
200
201
NDDITVKKDQ CLVRSFIDSK FYSIARKDIK EVDILNLPES ELSTKPGLQK
250
251
ASIFLKTRVV PDNWKMDISE ILESSSSDDE DGPAEENDEE KEKEAKKTEE
300
301
EVPEEELDPE ERDNFLQQLY KFMEDRGTPI NKPPVLGYKD LNLFKLFRLV
350
351
YHQGGCDNID SGAVWKQIYM DLGIPILNSA ASYNVKTAYR KYLYGFEEYC
400
401
RSANIQFRTV HHHEPKVKEE KKDLEESMEE ALKLDQEMPL TEVKSEPEEN
450
451
IDSNSESERE EIELKSPRGR RRIARDVNSI KKEIEEEKTE DKLKDNDTEN
500
501
KDVDDDYETA EKKENELLLG RKNTPKQKEK KIKKQEDSDK DSDEEEEKSQ
550
551
EREETESKCD SEGEEDEEDM EPCLTGTKVK VKYGRGKTQK IYEASIKSTE
600
601
IDDGEVLYLV HYYGWNVRYD EWVKADRIIW PLDKGGPKKK QKKKAKNKED
650
651
SEKDEKRDEE RQKSKRGRPP LKSTLSSNMP YGLSKTANSE GKSDSCSSDS
700
701
ETEDALEKNL INEELSLKDE LEKNENLNDD KLDEENPKIS AHILKENDRT
750
751
QMQPLETLKL EVGENEQIVQ IFGNKMEKTE EVKKEAEKSP KGKGRRSKTK
800
801
DLSLEIIKIS SFGQNEAGSE PHIEAHSLEL SSLDNKNFSS ATEDEIDQCV
850
851
KEKKLKRKIL GQSSPEKKIR IENGMEMTNT VSQERTSDCI GSEGMKNLNF
900
901
EQHFERENEG MPSLIAESNQ CIQQLTSERF DSPAEETVNI PLKEDEDAMP
950
951
LIGPETLVCH EVDLDDLDEK DKTSIEDVAV ESSESNSLVS IPPALPPVVQ
1000
1001
HNFSVASPLT LSQDESRSVK SESDITIEVD SIAEESQEGL CERESANGFE
1050
1051
TNVASGTCSI IVQERESREK GQKRPSDGNS GLMAKKQKRT PKRTSAAAKN
1100
1101
EKNGTGQSSD SEDLPVLDNS SKCTPVKHLN VSKPQKLARS PARISPHIKD
1150
1151
GEKDKHREKH PNSSPRTYKW SFQLNELDNM NSTERISFLQ EKLQEIRKYY
1200
1201
MSLKSEVATI DRRRKRLKKK DREVSHAGAS MSSASSDTGM SPSSSSPPQN
1250
1251
VLAVECR                                               
1257
 

Show the unformatted sequence.

Checksums:
CRC64:5B3F6A5AFB7588CF
MD5:6bbec11f058370d0fcfc1baa9712f14f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RBB1NT 170 - 262 2YRV A 8 - 100 NGL View in InterPro
Tudor-knot 574 - 630 2LCC A 7 - 63 NGL View in InterPro
6BPH A 574 - 630 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.