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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IL12B_HUMAN (P29460)

Summary

This is the summary of UniProt entry IL12B_HUMAN (P29460).

Description: Interleukin-12 subunit beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 328 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 97 107
Pfam IL12p40_C 126 216

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P29460. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD APGEMVVLTC
50
51
DTPEEDGITW TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS
100
101
LLLLHKKEDG IWSTDILKDQ KEPKNKTFLR CEAKNYSGRF TCWWLTTIST
150
151
DLTFSVKSSR GSSDPQGVTC GAATLSAERV RGDNKEYEYS VECQEDSACP
200
201
AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN LQLKPLKNSR
250
251
QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC
300
301
RKNASISVRA QDRYYSSSWS EWASVPCS                        
328
 

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Checksums:
CRC64:118FA801B8F5BB2F
MD5:6b899920020b6c34d11802cab8a9fb1d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IL12p40_C 126 - 216 1F42 A 104 - 194 NGL View in InterPro
1F45 A 104 - 194 NGL View in InterPro
3D85 D 104 - 194 NGL View in InterPro
3D87 B 104 - 194 NGL View in InterPro
D 104 - 194 NGL View in InterPro
3DUH A 104 - 194 NGL View in InterPro
B 104 - 194 NGL View in InterPro
3HMX A 104 - 194 NGL View in InterPro
3QWR A 104 - 194 NGL View in InterPro
4GRW B 104 - 194 NGL View in InterPro
D 104 - 194 NGL View in InterPro
5MJ3 A 126 - 216 NGL View in InterPro
5MJ4 A 126 - 216 NGL View in InterPro
5MXA A 126 - 216 NGL View in InterPro
5MZV A 126 - 216 NGL View in InterPro
5NJD A 126 - 216 NGL View in InterPro
C 126 - 216 NGL View in InterPro
E 126 - 216 NGL View in InterPro
G 126 - 216 NGL View in InterPro
I 126 - 216 NGL View in InterPro
K 126 - 216 NGL View in InterPro
6UIB B 104 - 194 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;