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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GARD_ECOLI (P39829)

Summary

This is the summary of UniProt entry GARD_ECOLI (P39829).

Description: Galactarate dehydratase (L-threo-forming) {ECO:0000255|HAMAP-Rule:MF_02031, ECO:0000303|PubMed:9772162}
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 523 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam SAF 22 92
Pfam GD_AH_C 118 522
low_complexity n/a 181 192
disorder n/a 357 358
disorder n/a 360 375
low_complexity n/a 472 484

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P39829. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MANIEIRQET PTAFYIKVHD TDNVAIIVND NGLKAGTRFP DGLELIEHIP
50
51
QGHKVALLDI PANGEIIRYG EVIGYAVRAI PRGSWIDESM VVLPEAPPLH
100
101
TLPLATKVPE PLPPLEGYTF EGYRNADGSV GTKNLLGITT SVHCVAGVVD
150
151
YVVKIIERDL LPKYPNVDGV VGLNHLYGCG VAINAPAAVV PIRTIHNISL
200
201
NPNFGGEVMV IGLGCEKLQP ERLLTGTDDV QAIPVESASI VSLQDEKHVG
250
251
FQSMVEDILQ IAERHLQKLN QRQRETCPAS ELVVGMQCGG SDAFSGVTAN
300
301
PAVGYASDLL VRCGATVMFS EVTEVRDAIH LLTPRAVNEE VGKRLLEEME
350
351
WYDNYLNMGK TDRSANPSPG NKKGGLANVV EKALGSIAKS GKSAIVEVLS
400
401
PGQRPTKRGL IYAATPASDF VCGTQQVASG ITVQVFTTGR GTPYGLMAVP
450
451
VIKMATRTEL ANRWFDLMDI NAGTIATGEE TIEEVGWKLF HFILDVASGK
500
501
KKTFSDQWGL HNQLAVFNPA PVT                             
523
 

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Checksums:
CRC64:919BCC8B49411BB0
MD5:78261d16ff6656ac479f4550b2ddd7e2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
GD_AH_C 118 - 522 6U7L A 118 - 522 Show 3D Structure View in InterPro
B 118 - 522 Show 3D Structure View in InterPro
C 118 - 522 Show 3D Structure View in InterPro
D 118 - 522 Show 3D Structure View in InterPro
SAF 22 - 92 3LAZ A 22 - 92 Show 3D Structure View in InterPro
B 22 - 92 Show 3D Structure View in InterPro
6U7L A 22 - 92 Show 3D Structure View in InterPro
B 22 - 92 Show 3D Structure View in InterPro
C 22 - 92 Show 3D Structure View in InterPro
D 22 - 92 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;