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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: GEA2_YEAST (P39993)

Summary

This is the summary of UniProt entry GEA2_YEAST (P39993).

Description: ARF guanine-nucleotide exchange factor 2
Source organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (NCBI taxonomy ID 559292)
Length: 1459 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 258 282
disorder n/a 284 297
disorder n/a 300 307
Pfam Sec7_N 332 493
low_complexity n/a 399 415
low_complexity n/a 445 459
disorder n/a 449 450
disorder n/a 550 551
Pfam Sec7 559 756
disorder n/a 681 687
disorder n/a 1013 1014
transmembrane n/a 1062 1081
low_complexity n/a 1332 1343
low_complexity n/a 1354 1364
disorder n/a 1414 1459

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P39993. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSDREFVTVD PVTIIIKECI NLSTAMRKYS KFTSQSGVAA LLGGGSEIFS
50
51
NQDDYLAHTF NNLNTNKHND PFLSGFIQLR LMLNKLKNLD NIDSLTILQP
100
101
FLLIVSTSSI SGYITSLALD SLQKFFTLNI INESSQNYIG AHRATVNALT
150
151
HCRFEGSQQL SDDSVLLKVV FLLRSIVDSP YGDLLSNSII YDVLQTILSL
200
201
ACNNRRSEVL RNAAQSTMIA VTVKIFSKLK TIEPVNVNQI YINDESYTND
250
251
VLKADTIGTN VESKEEGSQE DPIGMKVNNE EAISEDDGIE EEHIHSEKST
300
301
NGAEQLDIVQ KTTRSNSRIQ AYADDNYGLP VVRQYLNLLL SLIAPENELK
350
351
HSYSTRIFGL ELIQTALEIS GDRLQLYPRL FTLISDPIFK SILFIIQNTT
400
401
KLSLLQATLQ LFTTLVVILG NNLQLQIELT LTRIFSILLD DGTANNSSSE
450
451
NKNKPSIIKE LLIEQISILW TRSPSFFTST FINFDCNLDR ADVSINFLKA
500
501
LTKLALPESA LTTTESVPPI CLEGLVSLVD DMFDHMKDID REEFGRQKNE
550
551
MEILKKRDRK TEFIECTNAF NEKPKKGIPM LIEKGFIASD SDKDIAEFLF
600
601
NNNNRMNKKT IGLLLCHPDK VSLLNEYIRL FDFSGLRVDE AIRILLTKFR
650
651
LPGESQQIER IIEAFSSAYC ENQDYDPSKI SDNAEDDIST VQPDADSVFI
700
701
LSYSIIMLNT DLHNPQVKEH MSFEDYSGNL KGCCNHKDFP FWYLDRIYCS
750
751
IRDKEIVMPE EHHGNEKWFE DAWNNLISST TVITEIKKDT QSVMDKLTPL
800
801
ELLNFDRAIF KQVGPSIVST LFNIYVVASD DHISTRMITS LDKCSYISAF
850
851
FDFKDLFNDI LNSIAKGTTL INSSHDDELS TLAFEYGPMP LVQIKFEDTN
900
901
TEIPVSTDAV RFGRSFKGQL NTVVFFRIIR RNKDPKIFSK ELWLNIVNII
950
951
LTLYEDLILS PDIFPDLQKR LKLSNLPKPS PEISINKSKE SKGLLSTFAS
1000
1001
YLKGDEEPTE EEIKSSKKAM ECIKSSNIAA SVFGNESNIT ADLIKTLLDS
1050
1051
AKTEKNADNS RYFEAELLFI IELTIALFLF CKEEKELGKF ILQKVFQLSH
1100
1101
TKGLTKRTVR RMLTYKILLI SLCADQTEYL SKLINDELLK KGDIFTQKFF
1150
1151
ATNQGKEFLK RLFSLTESEF YRGFLLGNEN FWKFLRKVTA MKEQSESIFE
1200
1201
YLNESIKTDS NILTNENFMW VLGLLDEISS MGAVGNHWEI EYKKLTESGH
1250
1251
KIDKENPYKK SIELSLKSIQ LTSHLLEDNN DLRKNEIFAI IQALAHQCIN
1300
1301
PCKQISEFAV VTLEQTLINK IEIPTNEMES VEELIEGGLL PLLNSSETQE
1350
1351
DQKILISSIL TIISNVYLHY LKLGKTSNET FLKILSIFNK FVEDSDIEKK
1400
1401
LQQLILDKKS IEKGNGSSSH GSAHEQTPES NDVEIEATAP IDDNTDDDNK
1450
1451
PKLSDVEKD                                             
1459
 

Show the unformatted sequence.

Checksums:
CRC64:99DB9FDD34F863FA
MD5:5c32e7c317629d1ffb0665d1b3acf9bc

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Sec7 559 - 756 1KU1 A 559 - 756 NGL View in InterPro
B 559 - 756 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;