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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NNMT_HUMAN (P40261)

Summary

This is the summary of UniProt entry NNMT_HUMAN (P40261).

Description: Nicotinamide N-methyltransferase EC=2.1.1.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 264 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam NNMT_PNMT_TEMT 1 259

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P40261. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC
50
51
LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK
100
101
EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG
150
151
AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK
200
201
SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE
250
251
GLFSLVARKL SRPL                                       
264
 

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Checksums:
CRC64:280B12748F4488AC
MD5:9630d56c0ff23f5fc3dc85f12dadb4f3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NNMT_PNMT_TEMT 1 - 259 2IIP A 1 - 259 NGL View in InterPro
B 1 - 259 NGL View in InterPro
6B1A A 1 - 259 NGL View in InterPro
B 1 - 259 NGL View in InterPro
6CHH A 1 - 259 NGL View in InterPro
B 1 - 259 NGL View in InterPro
6ORR A 1 - 259 NGL View in InterPro
C 1 - 259 NGL View in InterPro
6PVE A 1 - 259 NGL View in InterPro
B 1 - 259 NGL View in InterPro
6PVS A 1 - 259 NGL View in InterPro
B 1 - 259 NGL View in InterPro
16 - 259 6B1A C 16 - 259 NGL View in InterPro
D 16 - 259 NGL View in InterPro
6CHH C 16 - 259 NGL View in InterPro
D 16 - 259 NGL View in InterPro
3 - 259 3ROD A 3 - 259 NGL View in InterPro
B 3 - 259 NGL View in InterPro
C 3 - 259 NGL View in InterPro
6PVS D 3 - 259 NGL View in InterPro
4 - 259 2IIP D 4 - 259 NGL View in InterPro
6PVS C 4 - 259 NGL View in InterPro
5 - 259 2IIP C 5 - 259 NGL View in InterPro
3ROD D 5 - 259 NGL View in InterPro
5YJF A 5 - 259 NGL View in InterPro
B 5 - 259 NGL View in InterPro
C 5 - 259 NGL View in InterPro
D 5 - 259 NGL View in InterPro
6ORR B 5 - 259 NGL View in InterPro
D 5 - 259 NGL View in InterPro
6PVE C 5 - 259 NGL View in InterPro
D 5 - 259 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.