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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: OPRX_HUMAN (P41146)

Summary

This is the summary of UniProt entry OPRX_HUMAN (P41146).

Description: Nociceptin receptor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 370 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 21 39
transmembrane n/a 55 77
Pfam 7tm_1 68 319
transmembrane n/a 89 107
low_complexity n/a 93 104
transmembrane n/a 113 132
transmembrane n/a 172 191
transmembrane n/a 211 239
low_complexity n/a 240 252
low_complexity n/a 256 273
transmembrane n/a 260 279
transmembrane n/a 299 322
low_complexity n/a 340 351

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P41146. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEPLFPAPFW EVIYGSHLQG NLSLLSPNHS LLPPHLLLNA SHGAFLPLGL
50
51
KVTIVGLYLA VCVGGLLGNC LVMYVILRHT KMKTATNIYI FNLALADTLV
100
101
LLTLPFQGTD ILLGFWPFGN ALCKTVIAID YYNMFTSTFT LTAMSVDRYV
150
151
AICHPIRALD VRTSSKAQAV NVAIWALASV VGVPVAIMGS AQVEDEEIEC
200
201
LVEIPTPQDY WGPVFAICIF LFSFIVPVLV ISVCYSLMIR RLRGVRLLSG
250
251
SREKDRNLRR ITRLVLVVVA VFVGCWTPVQ VFVLAQGLGV QPSSETAVAI
300
301
LRFCTALGYV NSCLNPILYA FLDENFKACF RKFCCASALR RDVQVSDRVR
350
351
SIAKDVALAC KTSETVPRPA                                 
370
 

Show the unformatted sequence.

Checksums:
CRC64:613700C0B4D093BA
MD5:e6951c5d57cc622eb06f65ac9917718f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
7tm_1 68 - 319 4EA3 A 68 - 319 NGL View in InterPro
B 68 - 319 NGL View in InterPro
5DHG A 68 - 319 NGL View in InterPro
B 1132 - 1383 NGL View in InterPro
5DHH A 68 - 319 NGL View in InterPro
B 1132 - 1383 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;