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50  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BCL6_HUMAN (P41182)

Summary

This is the summary of UniProt entry BCL6_HUMAN (P41182).

Description: B-cell lymphoma 6 protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 706 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam BTB 22 129
disorder n/a 219 220
disorder n/a 226 247
disorder n/a 258 282
disorder n/a 292 344
disorder n/a 350 370
disorder n/a 384 466
low_complexity n/a 457 466
disorder n/a 489 506
Pfam zf-C2H2 546 568
Pfam zf-C2H2 574 596
disorder n/a 590 592
Pfam zf-C2H2 602 624
Pfam zf-C2H2 630 652
disorder n/a 678 679
disorder n/a 688 690

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P41182. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL
50
51
MACSGLFYSI FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG
100
101
NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMVSAIKPPR EEFLNSRMLM
150
151
PQDIMAYRGR EVVENNLPLR SAPGCESRAF APSLYSGLST PPASYSMYSH
200
201
LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG EYSRPTLEVS
250
251
PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS
300
301
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS
350
351
KNACILQASG SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL
400
401
GRLSPRAYTA PPACQPPMEP ENLDLQSPTK LSASGEDSTI PQASRLNNIV
450
451
NRSMTGSPRS SSESHSPLYM HPPKCTSCGS QSPQHAEMCL HTAGPTFPEE
500
501
MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT HSDKPYKCDR
550
551
CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK
600
601
PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR
650
651
IHTGEKPYHC EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP
700
701
ELPKAC                                                
706
 

Show the unformatted sequence.

Checksums:
CRC64:E38D83C213DAE2D0
MD5:0010f4ad51f11d9ca36092c790a4afaf

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BTB 22 - 124 6ZBU J 22 - 124 NGL View in InterPro
22 - 125 5N1X D 22 - 125 NGL View in InterPro
6XYX A 22 - 125 NGL View in InterPro
B 22 - 125 NGL View in InterPro
6ZBU F 22 - 125 NGL View in InterPro
22 - 126 3BIM F 22 - 126 NGL View in InterPro
6XXS B 22 - 126 NGL View in InterPro
F 22 - 126 NGL View in InterPro
22 - 127 3BIM H 22 - 127 NGL View in InterPro
3E4U D 22 - 127 NGL View in InterPro
E 22 - 127 NGL View in InterPro
F 22 - 127 NGL View in InterPro
4CP3 A 22 - 127 NGL View in InterPro
4U2M A 145 - 250 NGL View in InterPro
B 145 - 250 NGL View in InterPro
C 145 - 250 NGL View in InterPro
D 145 - 250 NGL View in InterPro
5MW6 A 22 - 127 NGL View in InterPro
B 22 - 127 NGL View in InterPro
5N1X B 22 - 127 NGL View in InterPro
C 22 - 127 NGL View in InterPro
6XWF A 22 - 127 NGL View in InterPro
6XXS A 22 - 127 NGL View in InterPro
E 22 - 127 NGL View in InterPro
6Y17 B 22 - 127 NGL View in InterPro
6ZBU E 22 - 127 NGL View in InterPro
I 22 - 127 NGL View in InterPro
22 - 128 1R28 A 22 - 128 NGL View in InterPro
B 22 - 128 NGL View in InterPro
1R29 A 22 - 128 NGL View in InterPro
1R2B B 22 - 128 NGL View in InterPro
3BIM B 22 - 128 NGL View in InterPro
D 22 - 128 NGL View in InterPro
E 22 - 128 NGL View in InterPro
G 22 - 128 NGL View in InterPro
3E4U A 22 - 128 NGL View in InterPro
C 22 - 128 NGL View in InterPro
3LBZ A 22 - 128 NGL View in InterPro
B 22 - 128 NGL View in InterPro
4CP3 B 22 - 128 NGL View in InterPro
5H7G A 22 - 128 NGL View in InterPro
B 22 - 128 NGL View in InterPro
5MW2 A 22 - 128 NGL View in InterPro
5MWD A 22 - 128 NGL View in InterPro
5N1X A 22 - 128 NGL View in InterPro
5N1Z A 22 - 128 NGL View in InterPro
5N20 A 22 - 128 NGL View in InterPro
5N21 A 22 - 128 NGL View in InterPro
B 22 - 128 NGL View in InterPro
6C3L A 22 - 128 NGL View in InterPro
B 22 - 128 NGL View in InterPro
6C3N B 22 - 128 NGL View in InterPro
6CQ1 A 22 - 128 NGL View in InterPro
B 22 - 128 NGL View in InterPro
6EW6 A 22 - 128 NGL View in InterPro
6EW7 A 22 - 128 NGL View in InterPro
B 22 - 128 NGL View in InterPro
6EW8 A 22 - 128 NGL View in InterPro
6XMX A 22 - 128 NGL View in InterPro
B 22 - 128 NGL View in InterPro
C 22 - 128 NGL View in InterPro
D 22 - 128 NGL View in InterPro
E 22 - 128 NGL View in InterPro
F 22 - 128 NGL View in InterPro
G 22 - 128 NGL View in InterPro
H 22 - 128 NGL View in InterPro
6XZZ A 22 - 128 NGL View in InterPro
6Y17 A 22 - 128 NGL View in InterPro
6ZBU A 22 - 128 NGL View in InterPro
22 - 129 1R2B A 22 - 129 NGL View in InterPro
3BIM A 22 - 129 NGL View in InterPro
C 22 - 129 NGL View in InterPro
3E4U B 22 - 129 NGL View in InterPro
5H7H A 22 - 129 NGL View in InterPro
5X4M A 22 - 129 NGL View in InterPro
5X4N A 22 - 129 NGL View in InterPro
5X4O A 22 - 129 NGL View in InterPro
5X4P A 22 - 129 NGL View in InterPro
5X4Q A 22 - 129 NGL View in InterPro
5X9O A 22 - 129 NGL View in InterPro
5X9P A 22 - 129 NGL View in InterPro
6C3N A 22 - 129 NGL View in InterPro
6TOF A 22 - 129 NGL View in InterPro
6TOG A 22 - 129 NGL View in InterPro
6TOH A 22 - 129 NGL View in InterPro
6TOI A 22 - 129 NGL View in InterPro
6TOJ A 22 - 129 NGL View in InterPro
6TOK A 22 - 129 NGL View in InterPro
6TOL A 22 - 129 NGL View in InterPro
6TOM A 22 - 129 NGL View in InterPro
6TON A 22 - 129 NGL View in InterPro
6TOO A 22 - 129 NGL View in InterPro
6ZBU B 22 - 129 NGL View in InterPro
zf-C2H2 574 - 596 2LCE A 46 - 68 NGL View in InterPro
602 - 624 2EN2 A 12 - 34 NGL View in InterPro
630 - 652 2EOS A 12 - 34 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.