Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
34  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MTOR_HUMAN (P42345)

Summary

This is the summary of UniProt entry MTOR_HUMAN (P42345).

Description: Serine/threonine-protein kinase mTOR
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2549 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 3 10
low_complexity n/a 7 15
disorder n/a 32 38
disorder n/a 42 43
disorder n/a 50 51
low_complexity n/a 179 191
disorder n/a 229 233
disorder n/a 246 253
low_complexity n/a 277 288
disorder n/a 285 287
disorder n/a 317 318
disorder n/a 558 561
disorder n/a 563 564
coiled_coil n/a 676 696
low_complexity n/a 774 790
Pfam DUF3385 854 1024
low_complexity n/a 913 923
low_complexity n/a 916 932
low_complexity n/a 1279 1300
low_complexity n/a 1510 1520
Pfam FAT 1513 1908
low_complexity n/a 1610 1622
low_complexity n/a 1666 1677
disorder n/a 1730 1738
disorder n/a 1809 1868
low_complexity n/a 1820 1863
Pfam FRB_dom 2015 2113
Pfam PI3_PI4_kinase 2181 2431
disorder n/a 2437 2446
disorder n/a 2466 2470
disorder n/a 2474 2475
Pfam FATC 2518 2549

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P42345. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLGTGPAAAT TAATTSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM
50
51
ELREMSQEES TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN
100
101
ATRIGRFANY LRNLLPSNDP VVMEMASKAI GRLAMAGDTF TAEYVEFEVK
150
151
RALEWLGADR NEGRRHAAVL VLRELAISVP TFFFQQVQPF FDNIFVAVWD
200
201
PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE AEKGFDETLA
250
251
KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC
300
301
KDLMGFGTKP RHITPFTSFQ AVQPQQSNAL VGLLGYSSHQ GLMGFGTSPS
350
351
PAKSTLVESR CCRDLMEEKF DQVCQWVLKC RNSKNSLIQM TILNLLPRLA
400
401
AFRPSAFTDT QYLQDTMNHV LSCVKKEKER TAAFQALGLL SVAVRSEFKV
450
451
YLPRVLDIIR AALPPKDFAH KRQKAMQVDA TVFTCISMLA RAMGPGIQQD
500
501
IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL KMLSLVLMHK
550
551
PLRHPGMPKG LAHQLASPGL TTLPEASDVG SITLALRTLG SFEFEGHSLT
600
601
QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ
650
651
VVADVLSKLL VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL
700
701
NDQVFEIREL AICTVGRLSS MNPAFVMPFL RKMLIQILTE LEHSGIGRIK
750
751
EQSARMLGHL VSNAPRLIRP YMEPILKALI LKLKDPDPDP NPGVINNVLA
800
801
TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA LWTLGQLVAS
850
851
TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK
900
901
VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV
950
951
SMVALMRIFR DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV
1000
1001
IRVCDGAIRE FLFQQLGMLV SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS
1050
1051
TIILLIEQIV VALGGEFKLY LPQLIPHMLR VFMHDNSPGR IVSIKLLAAI
1100
1101
QLFGANLDDY LHLLLPPIVK LFDAPEAPLP SRKAALETVD RLTESLDFTD
1150
1151
YASRIIHPIV RTLDQSPELR STAMDTLSSL VFQLGKKYQI FIPMVNKVLV
1200
1201
RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSG QGDALASGPV
1250
1251
ETGPMKKLHV STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL
1300
1301
RSCWALAQAY NPMARDLFNA AFVSCWSELN EDQQDELIRS IELALTSQDI
1350
1351
AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI VLLGERAAKC RAYAKALHYK
1400
1401
ELEFQKGPTP AILESLISIN NKLQQPEAAA GVLEYAMKHF GELEIQATWY
1450
1451
EKLHEWEDAL VAYDKKMDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK
1500
1501
WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL
1550
1551
ALHQDLFSLA QQCIDKARDL LDAELTAMAG ESYSRAYGAM VSCHMLSELE
1600
1601
EVIQYKLVPE RREIIRQIWW ERLQGCQRIV EDWQKILMVR SLVVSPHEDM
1650
1651
RTWLKYASLC GKSGRLALAH KTLVLLLGVD PSRQLDHPLP TVHPQVTYAY
1700
1701
MKNMWKSARK IDAFQHMQHF VQTMQQQAQH AIATEDQQHK QELHKLMARC
1750
1751
FLKLGEWQLN LQGINESTIP KVLQYYSAAT EHDRSWYKAW HAWAVMNFEA
1800
1801
VLHYKHQNQA RDEKKKLRHA SGANITNATT AATTAATATT TASTEGSNSE
1850
1851
SEAESTENSP TPSPLQKKVT EDLSKTLLMY TVPAVQGFFR SISLSRGNNL
1900
1901
QDTLRVLTLW FDYGHWPDVN EALVEGVKAI QIDTWLQVIP QLIARIDTPR
1950
1951
PLVGRLIHQL LTDIGRYHPQ ALIYPLTVAS KSTTTARHNA ANKILKNMCE
2000
2001
HSNTLVQQAM MVSEELIRVA ILWHEMWHEG LEEASRLYFG ERNVKGMFEV
2050
2051
LEPLHAMMER GPQTLKETSF NQAYGRDLME AQEWCRKYMK SGNVKDLTQA
2100
2101
WDLYYHVFRR ISKQLPQLTS LELQYVSPKL LMCRDLELAV PGTYDPNQPI
2150
2151
IRIQSIAPSL QVITSKQRPR KLTLMGSNGH EFVFLLKGHE DLRQDERVMQ
2200
2201
LFGLVNTLLA NDPTSLRKNL SIQRYAVIPL STNSGLIGWV PHCDTLHALI
2250
2251
RDYREKKKIL LNIEHRIMLR MAPDYDHLTL MQKVEVFEHA VNNTAGDDLA
2300
2301
KLLWLKSPSS EVWFDRRTNY TRSLAVMSMV GYILGLGDRH PSNLMLDRLS
2350
2351
GKILHIDFGD CFEVAMTREK FPEKIPFRLT RMLTNAMEVT GLDGNYRITC
2400
2401
HTVMEVLREH KDSVMAVLEA FVYDPLLNWR LMDTNTKGNK RSRTRTDSYS
2450
2451
AGQSVEILDG VELGEPAHKK TGTTVPESIH SFIGDGLVKP EALNKKAIQI
2500
2501
INRVRDKLTG RDFSHDDTLD VPTQVELLIK QATSHENLCQ CYIGWCPFW 
2549
 

Show the unformatted sequence.

Checksums:
CRC64:7D9AD6E784882AB4
MD5:d3be1a657b7fdb5ab4c03e12d4452164

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DUF3385 854 - 1024 5H64 A 854 - 1024 Show 3D Structure View in InterPro
a 854 - 1024 Show 3D Structure View in InterPro
5ZCS A 854 - 1024 Show 3D Structure View in InterPro
B 854 - 1024 Show 3D Structure View in InterPro
6BCU A 854 - 1024 Show 3D Structure View in InterPro
B 854 - 1024 Show 3D Structure View in InterPro
6BCX A 854 - 1024 Show 3D Structure View in InterPro
B 854 - 1024 Show 3D Structure View in InterPro
6SB0 A 854 - 1024 Show 3D Structure View in InterPro
B 854 - 1024 Show 3D Structure View in InterPro
6SB2 A 854 - 1024 Show 3D Structure View in InterPro
B 854 - 1024 Show 3D Structure View in InterPro
6ZWM A 854 - 1024 Show 3D Structure View in InterPro
B 854 - 1024 Show 3D Structure View in InterPro
6ZWO B 854 - 1024 Show 3D Structure View in InterPro
FAT 1513 - 1908 3JBZ A 1513 - 1908 Show 3D Structure View in InterPro
4JSN A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
4JSP A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
4JSV A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
4JSX A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
4JT5 A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
4JT6 A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
5FLC B 1513 - 1908 Show 3D Structure View in InterPro
F 1513 - 1908 Show 3D Structure View in InterPro
5H64 A 1513 - 1908 Show 3D Structure View in InterPro
a 1513 - 1908 Show 3D Structure View in InterPro
5WBU A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
5WBY A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
5ZCS A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
6BCU A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
6BCX A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
6SB0 A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
6SB2 A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
6ZWM A 1513 - 1908 Show 3D Structure View in InterPro
B 1513 - 1908 Show 3D Structure View in InterPro
6ZWO B 1513 - 1908 Show 3D Structure View in InterPro
FATC 2518 - 2549 3JBZ A 2518 - 2549 Show 3D Structure View in InterPro
4JSN A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
4JSP A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
4JSV A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
4JSX A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
4JT5 A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
4JT6 A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
5FLC B 2518 - 2549 Show 3D Structure View in InterPro
F 2518 - 2549 Show 3D Structure View in InterPro
5H64 A 2518 - 2549 Show 3D Structure View in InterPro
a 2518 - 2549 Show 3D Structure View in InterPro
5WBU A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
5WBY A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
5ZCS A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
6BCU A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
6BCX A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
6SB0 A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
6SB2 A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
6ZWM A 2518 - 2549 Show 3D Structure View in InterPro
B 2518 - 2549 Show 3D Structure View in InterPro
6ZWO B 2518 - 2549 Show 3D Structure View in InterPro
FRB_dom 2015 - 2020 3JBZ A 2015 - 2020 Show 3D Structure View in InterPro
2015 - 2113 2GAQ A 1 - 99 Show 3D Structure View in InterPro
2NPU A 2015 - 2113 Show 3D Structure View in InterPro
4JSN A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
4JSP A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
4JSV A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
4JSX A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
4JT5 A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
4JT6 A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
5FLC B 2015 - 2113 Show 3D Structure View in InterPro
F 2015 - 2113 Show 3D Structure View in InterPro
5H64 A 2015 - 2113 Show 3D Structure View in InterPro
a 2015 - 2113 Show 3D Structure View in InterPro
5WBU A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
5WBY A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
5ZCS A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
6BCU A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
6BCX A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
6SB0 A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
6SB2 A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
6ZWM A 2015 - 2113 Show 3D Structure View in InterPro
B 2015 - 2113 Show 3D Structure View in InterPro
6ZWO B 2015 - 2113 Show 3D Structure View in InterPro
2018 - 2112 1FAP B 2018 - 2112 Show 3D Structure View in InterPro
2018 - 2113 5WBH C 2018 - 2113 Show 3D Structure View in InterPro
2019 - 2112 1NSG B 2019 - 2112 Show 3D Structure View in InterPro
2FAP B 2019 - 2112 Show 3D Structure View in InterPro
2RSE B 1009 - 1102 Show 3D Structure View in InterPro
3FAP B 108 - 201 Show 3D Structure View in InterPro
4FAP B 108 - 201 Show 3D Structure View in InterPro
2021 - 2112 5GPG B 2021 - 2112 Show 3D Structure View in InterPro
6M4W G 2021 - 2112 Show 3D Structure View in InterPro
H 2021 - 2112 Show 3D Structure View in InterPro
I 2021 - 2112 Show 3D Structure View in InterPro
2021 - 2113 1AUE B 2022 - 2114 Show 3D Structure View in InterPro
6M4U B 2021 - 2113 Show 3D Structure View in InterPro
F 2021 - 2113 Show 3D Structure View in InterPro
2022 - 2113 1AUE A 2023 - 2114 Show 3D Structure View in InterPro
5WBH A 2022 - 2113 Show 3D Structure View in InterPro
B 2022 - 2113 Show 3D Structure View in InterPro
D 2022 - 2113 Show 3D Structure View in InterPro
E 2022 - 2113 Show 3D Structure View in InterPro
2025 - 2112 4DRH B 2025 - 2112 Show 3D Structure View in InterPro
E 2025 - 2112 Show 3D Structure View in InterPro
4DRI B 2025 - 2112 Show 3D Structure View in InterPro
2025 - 2113 4DRJ B 2025 - 2113 Show 3D Structure View in InterPro
PI3_PI4_kinase 2181 - 2431 3JBZ A 2181 - 2431 Show 3D Structure View in InterPro
4JSN A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
4JSP A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
4JSV A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
4JSX A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
4JT5 A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
4JT6 A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
5FLC B 2181 - 2431 Show 3D Structure View in InterPro
F 2181 - 2431 Show 3D Structure View in InterPro
5H64 A 2181 - 2431 Show 3D Structure View in InterPro
a 2181 - 2431 Show 3D Structure View in InterPro
5WBU A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
5WBY A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
5ZCS A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
6BCU A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
6BCX A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
6SB0 A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
6SB2 A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
6ZWM A 2181 - 2431 Show 3D Structure View in InterPro
B 2181 - 2431 Show 3D Structure View in InterPro
6ZWO B 2181 - 2431 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;