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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RXRG_HUMAN (P48443)

Summary

This is the summary of UniProt entry RXRG_HUMAN (P48443).

Description: Retinoic acid receptor RXR-gamma
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 463 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 16 54
Pfam Nuc_recep-AF1 25 134
disorder n/a 56 58
low_complexity n/a 76 89
disorder n/a 87 89
low_complexity n/a 97 109
disorder n/a 103 106
disorder n/a 117 124
Pfam zf-C4 137 206
low_complexity n/a 185 199
low_complexity n/a 206 225
disorder n/a 210 227
disorder n/a 251 260
Pfam Hormone_recep 255 443
disorder n/a 264 265

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P48443. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV
50
51
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL
100
101
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
150
151
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
200
201
VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL EAELAVEPKT
250
251
ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
300
301
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
350
351
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
400
401
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT
450
451
FLMEMLETPL QIT                                        
463
 

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Checksums:
CRC64:AED5C94BB62A3157
MD5:dd71b0a70a77541ade1b806140bcd84b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Hormone_recep 262 - 443 7A79 A 262 - 443 NGL View in InterPro
B 262 - 443 NGL View in InterPro
272 - 443 2GL8 A 50 - 221 NGL View in InterPro
B 50 - 221 NGL View in InterPro
C 50 - 221 NGL View in InterPro
D 50 - 221 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;