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31  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KC1D_HUMAN (P48730)

Summary

This is the summary of UniProt entry KC1D_HUMAN (P48730).

Description: Casein kinase I isoform delta EC=2.7.11.1 EC=2.7.11.26
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 415 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Pkinase 9 271
low_complexity n/a 299 314
disorder n/a 301 415

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P48730. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH
50
51
IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF
100
101
SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF
150
151
GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG
200
201
YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT
250
251
YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
300
301
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS
350
351
HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI
400
401
PGRVASSGLQ SVVHR                                      
415
 

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Checksums:
CRC64:B97F1717A52466D2
MD5:f6cb250af125a396596a42297e16bc0a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 9 - 271 3UYS A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
3UYT A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
3UZP A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
4HGT A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
4HNF A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
4KB8 A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
4KBA A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
4KBC A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
4KBK A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
4TN6 A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
4TW9 A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
4TWC A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
5IH4 A 9 - 271 NGL View in InterPro
5IH5 A 9 - 271 NGL View in InterPro
5IH6 A 9 - 271 NGL View in InterPro
5MQV A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
E 9 - 271 NGL View in InterPro
F 9 - 271 NGL View in InterPro
5OKT A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
5W4W A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
6F1W A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6F26 A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6GZM A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6HMP A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6HMR A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6PXN A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6PXO A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6PXP A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6RCG A 9 - 271 NGL View in InterPro
6RCH A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6RU6 A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6RU7 A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
6RU8 A 9 - 271 NGL View in InterPro
B 9 - 271 NGL View in InterPro
C 9 - 271 NGL View in InterPro
D 9 - 271 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;