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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ARRB1_HUMAN (P49407)

Summary

This is the summary of UniProt entry ARRB1_HUMAN (P49407).

Description: Beta-arrestin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 418 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Arrestin_N 18 174
low_complexity n/a 32 45
disorder n/a 91 93
disorder n/a 175 191
Pfam Arrestin_C 193 356
low_complexity n/a 214 235
disorder n/a 288 291
disorder n/a 300 302
low_complexity n/a 322 329
disorder n/a 349 379
low_complexity n/a 353 367
disorder n/a 397 418
low_complexity n/a 400 408

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49407. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE
50
51
RRVYVTLTCA FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL
100
101
QERLIKKLGE HAYPFTFEIP PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC
150
151
AENLEEKIHK RNSVRLVIRK VQYAPERPGP QPTAETTRQF LMSDKPLHLE
200
201
ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD ICLFNTAQYK
250
251
CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL
300
301
ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT
350
351
LMHPKPKEEP PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK
400
401
DDKEEEEDGT GSPQLNNR                                   
418
 

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Checksums:
CRC64:0A3C135092338D10
MD5:97b9b3aa11f5fa94d0d291671727a5a9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Arrestin_C 193 - 355 6UP7 B 193 - 355 NGL View in InterPro
193 - 356 6PWC A 193 - 356 NGL View in InterPro
6TKO B 193 - 356 NGL View in InterPro
Arrestin_N 18 - 174 6PWC A 18 - 174 NGL View in InterPro
6TKO B 18 - 174 NGL View in InterPro
6UP7 B 18 - 174 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;