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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TAF6_HUMAN (P49848)

Summary

This is the summary of UniProt entry TAF6_HUMAN (P49848).

Description: Transcription initiation factor TFIID subunit 6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 677 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam TAF 11 76
disorder n/a 142 204
low_complexity n/a 142 161
Pfam TAF6_C 308 397
disorder n/a 439 440
disorder n/a 442 443
disorder n/a 445 447
low_complexity n/a 462 477
disorder n/a 475 509
disorder n/a 520 545
low_complexity n/a 523 535
low_complexity n/a 542 546
disorder n/a 549 677
low_complexity n/a 554 578
low_complexity n/a 586 602
low_complexity n/a 621 641

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49848. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI
50
51
AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG
100
101
GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP
150
151
PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGATTADG KGKEKKAPPL
200
201
LEGAPLRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP
250
251
GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY
300
301
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN
350
351
IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG
400
401
ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRA
450
451
EFGSLGPLLC SQVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG
500
501
PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSAPST
550
551
QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPSGP
600
601
GSVQKYIVVS LPPTGEGKGG PTSHPSPVPP PASSPSPLSG SALCGGKQEA
650
651
GDSPPPAPGT PKANGSQPNS GSPQPAP                         
677
 

Show the unformatted sequence.

Checksums:
CRC64:06C6BFA563580823
MD5:d44eae525067b9f4204e967bf64fc769

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TAF 11 - 76 6F3T E 11 - 76 NGL View in InterPro
G 11 - 76 NGL View in InterPro
I 11 - 76 NGL View in InterPro
K 11 - 76 NGL View in InterPro
6MZC I 11 - 76 NGL View in InterPro
6MZD H 11 - 76 NGL View in InterPro
6MZL H 11 - 76 NGL View in InterPro
I 11 - 76 NGL View in InterPro
6MZM I 11 - 76 NGL View in InterPro
TAF6_C 308 - 397 5FUR J 308 - 397 NGL View in InterPro
K 308 - 397 NGL View in InterPro
6MZC H 308 - 397 NGL View in InterPro
I 308 - 397 NGL View in InterPro
6MZL H 308 - 397 NGL View in InterPro
I 308 - 397 NGL View in InterPro
6MZM H 308 - 397 NGL View in InterPro
I 308 - 397 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;