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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: END8_ECOLI (P50465)

Summary

This is the summary of UniProt entry END8_ECOLI (P50465).

Description: Endonuclease 8 EC=3.2.2.- EC=4.2.99.18
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 263 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Fapy_DNA_glyco 1 107
disorder n/a 1 6
disorder n/a 9 12
disorder n/a 88 89
Pfam H2TH 126 216
low_complexity n/a 190 203
Pfam zf-FPG_IleRS 235 263

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P50465. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPEGPEIRRA ADNLEAAIKG KPLTDVWFAF PQLKPYQSQL IGQHVTHVET
50
51
RGKALLTHFS NDLTLYSHNQ LYGVWRVVDT GEEPQTTRVL RVKLQTADKT
100
101
ILLYSASDIE MLTPEQLTTH PFLQRVGPDV LDPNLTPEVV KERLLSPRFR
150
151
NRQFAGLLLD QAFLAGLGNY LRVEILWQVG LTGNHKAKDL NAAQLDALAH
200
201
ALLEIPRFSY ATRGQVDENK HHGALFRFKV FHRDGEPCER CGSIIEKTTL
250
251
SSRPFYWCPG CQH                                        
263
 

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Checksums:
CRC64:7D10B79F58ADDA24
MD5:8d4f5fd2e953748336a91be9d21b88fb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Fapy_DNA_glyco 2 - 107 1K3W A 1 - 106 Show 3D Structure View in InterPro
1K3X A 1 - 106 Show 3D Structure View in InterPro
1Q3B A 1 - 106 Show 3D Structure View in InterPro
2EA0 A 1 - 106 Show 3D Structure View in InterPro
2OPF A 1 - 106 Show 3D Structure View in InterPro
2OQ4 A 1 - 106 Show 3D Structure View in InterPro
B 1 - 106 Show 3D Structure View in InterPro
6FBU A 1 - 106 Show 3D Structure View in InterPro
3 - 107 1Q3C A 2 - 106 Show 3D Structure View in InterPro
5 - 107 1Q39 A 4 - 106 Show 3D Structure View in InterPro
H2TH 126 - 213 2OQ4 B 125 - 212 Show 3D Structure View in InterPro
126 - 214 1K3X A 125 - 213 Show 3D Structure View in InterPro
1Q3C A 125 - 213 Show 3D Structure View in InterPro
2OQ4 A 125 - 213 Show 3D Structure View in InterPro
126 - 215 1K3W A 125 - 214 Show 3D Structure View in InterPro
2EA0 A 125 - 214 Show 3D Structure View in InterPro
6FBU A 125 - 214 Show 3D Structure View in InterPro
126 - 216 1Q39 A 125 - 215 Show 3D Structure View in InterPro
1Q3B A 125 - 215 Show 3D Structure View in InterPro
2OPF A 125 - 215 Show 3D Structure View in InterPro
zf-FPG_IleRS 235 - 263 1K3W A 234 - 262 Show 3D Structure View in InterPro
1K3X A 234 - 262 Show 3D Structure View in InterPro
1Q39 A 234 - 262 Show 3D Structure View in InterPro
1Q3B A 234 - 262 Show 3D Structure View in InterPro
1Q3C A 234 - 262 Show 3D Structure View in InterPro
2EA0 A 234 - 262 Show 3D Structure View in InterPro
2OPF A 234 - 262 Show 3D Structure View in InterPro
2OQ4 A 234 - 262 Show 3D Structure View in InterPro
B 234 - 262 Show 3D Structure View in InterPro
6FBU A 234 - 262 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;