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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AP4A_HUMAN (P50583)

Summary

This is the summary of UniProt entry AP4A_HUMAN (P50583).

Description: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] EC=3.6.1.17
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 147 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam NUDIX 12 137
disorder n/a 39 44
disorder n/a 46 58

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P50583. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALRACGLII FRRCLIPKVD NNAIEFLLLQ ASDGIHHWTP PKGHVEPGED
50
51
DLETALRETQ EEAGIEAGQL TIIEGFKREL NYVARNKPKT VIYWLAEVKD
100
101
YDVEIRLSHE HQAYRWLGLE EACQLAQFKE MKAALQEGHQ FLCSIEA   
147
 

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Checksums:
CRC64:3599B12719F94AB8
MD5:1d7655be8e5aff0f98659ac9c9bda479

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NUDIX 12 - 137 1XSA A 17 - 142 NGL View in InterPro
1XSB A 17 - 142 NGL View in InterPro
1XSC A 17 - 142 NGL View in InterPro
3U53 A 12 - 137 NGL View in InterPro
B 12 - 137 NGL View in InterPro
C 12 - 137 NGL View in InterPro
D 12 - 137 NGL View in InterPro
4ICK A 12 - 137 NGL View in InterPro
B 12 - 137 NGL View in InterPro
4IJX A 12 - 137 NGL View in InterPro
B 12 - 137 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.