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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ATX1_HUMAN (P54253)

Summary

This is the summary of UniProt entry ATX1_HUMAN (P54253).

Description: Ataxin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 815 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam ATXN-1_C 1 558
disorder n/a 1 75
low_complexity n/a 47 64
disorder n/a 78 123
low_complexity n/a 88 99
disorder n/a 141 148
disorder n/a 150 441
low_complexity n/a 154 169
coiled_coil n/a 194 224
low_complexity n/a 197 226
low_complexity n/a 365 376
disorder n/a 447 449
disorder n/a 495 496
low_complexity n/a 554 572
Pfam AXH 574 687
disorder n/a 701 704
disorder n/a 718 745
disorder n/a 755 799

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P54253. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKSNQERSNE CLPPKKREIP ATSRSSEEKA PTLPSDNHRV EGTAWLPGNP
50
51
GGRGHGGGRH GPAGTSVELG LQQGIGLHKA LSTGLDYSPP SAPRSVPVAT
100
101
TLPAAYATPQ PGTPVSPVQY AHLPHTFQFI GSSQYSGTYA SFIPSQLIPP
150
151
TANPVTSAVA SAAGATTPSQ RSQLEAYSTL LANMGSLSQT PGHKAEQQQQ
200
201
QQQQQQQQHQ HQQQQQQQQQ QQQQQHLSRA PGLITPGSPP PAQQNQYVHI
250
251
SSSPQNTGRT ASPPAIPVHL HPHQTMIPHT LTLGPPSQVV MQYADSGSHF
300
301
VPREATKKAE SSRLQQAIQA KEVLNGEMEK SRRYGAPSSA DLGLGKAGGK
350
351
SVPHPYESRH VVVHPSPSDY SSRDPSGVRA SVMVLPNSNT PAADLEVQQA
400
401
THREASPSTL NDKSGLHLGK PGHRSYALSP HTVIQTTHSA SEPLPVGLPA
450
451
TAFYAGTQPP VIGYLSGQQQ AITYAGSLPQ HLVIPGTQPL LIPVGSTDME
500
501
ASGAAPAIVT SSPQFAAVPH TFVTTALPKS ENFNPEALVT QAAYPAMVQA
550
551
QIHLPVVQSV ASPAAAPPTL PPYFMKGSII QLANGELKKV EDLKTEDFIQ
600
601
SAEISNDLKI DSSTVERIED SHSPGVAVIQ FAVGEHRAQV SVEVLVEYPF
650
651
FVFGQGWSSC CPERTSQLFD LPCSKLSVGD VCISLTLKNL KNGSVKKGQP
700
701
VDPASVLLKH SKADGLAGSR HRYAEQENGI NQGSAQMLSE NGELKFPEKM
750
751
GLPAAPFLTK IEPSKPAATR KRRWSAPESR KLEKSEDEPP LTLPKPSLIP
800
801
QEVKICIEGR SNVGK                                      
815
 

Show the unformatted sequence.

Checksums:
CRC64:657876F8FD19ECB2
MD5:fd43d913d24ccf8093256d24a010204a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AXH 574 - 685 4J2J C 575 - 686 Show 3D Structure View in InterPro
574 - 687 1OA8 A 575 - 688 Show 3D Structure View in InterPro
B 575 - 688 Show 3D Structure View in InterPro
C 575 - 688 Show 3D Structure View in InterPro
D 575 - 688 Show 3D Structure View in InterPro
2M41 B 575 - 688 Show 3D Structure View in InterPro
4APT A 575 - 688 Show 3D Structure View in InterPro
B 575 - 688 Show 3D Structure View in InterPro
C 575 - 688 Show 3D Structure View in InterPro
D 575 - 688 Show 3D Structure View in InterPro
4AQP A 575 - 688 Show 3D Structure View in InterPro
B 575 - 688 Show 3D Structure View in InterPro
C 575 - 688 Show 3D Structure View in InterPro
D 575 - 688 Show 3D Structure View in InterPro
4J2J A 575 - 688 Show 3D Structure View in InterPro
B 575 - 688 Show 3D Structure View in InterPro
4J2L A 575 - 688 Show 3D Structure View in InterPro
B 575 - 688 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;