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23  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EPHB4_HUMAN (P54760)

Summary

This is the summary of UniProt entry EPHB4_HUMAN (P54760).

Description: Ephrin type-B receptor 4 EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 987 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 21
low_complexity n/a 10 28
Pfam Ephrin_lbd 18 197
Pfam Ephrin_rec_like 258 304
disorder n/a 317 327
Pfam fn3 325 417
disorder n/a 420 421
disorder n/a 423 431
disorder n/a 433 440
Pfam fn3 435 519
disorder n/a 515 516
disorder n/a 518 527
transmembrane n/a 538 563
low_complexity n/a 538 561
Pfam EphA2_TM 541 612
Pfam PK_Tyr_Ser-Thr 615 874
disorder n/a 897 900
Pfam SAM_1 905 969
disorder n/a 965 987
low_complexity n/a 974 983

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P54760. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MELRVLLCWA SLAAALEETL LNTKLETADL KWVTFPQVDG QWEELSGLDE
50
51
EQHSVRTYEV CDVQRAPGQA HWLRTGWVPR RGAVHVYATL RFTMLECLSL
100
101
PRAGRSCKET FTVFYYESDA DTATALTPAW MENPYIKVDT VAAEHLTRKR
150
151
PGAEATGKVN VKTLRLGPLS KAGFYLAFQD QGACMALLSL HLFYKKCAQL
200
201
TVNLTRFPET VPRELVVPVA GSCVVDAVPA PGPSPSLYCR EDGQWAEQPV
250
251
TGCSCAPGFE AAEGNTKCRA CAQGTFKPLS GEGSCQPCPA NSHSNTIGSA
300
301
VCQCRVGYFR ARTDPRGAPC TTPPSAPRSV VSRLNGSSLH LEWSAPLESG
350
351
GREDLTYALR CRECRPGGSC APCGGDLTFD PGPRDLVEPW VVVRGLRPDF
400
401
TYTFEVTALN GVSSLATGPV PFEPVNVTTD REVPPAVSDI RVTRSSPSSL
450
451
SLAWAVPRAP SGAVLDYEVK YHEKGAEGPS SVRFLKTSEN RAELRGLKRG
500
501
ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE SEGWREQLAL IAGTAVVGVV
550
551
LVLVVIVVAV LCLRKQSNGR EAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN
600
601
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK
650
651
GGYTERQRRE FLSEASIMGQ FEHPNIIRLE GVVTNSMPVM ILTEFMENGA
700
701
LDSFLRLNDG QFTVIQLVGM LRGIASGMRY LAEMSYVHRD LAARNILVNS
750
751
NLVCKVSDFG LSRFLEENSS DPTYTSSLGG KIPIRWTAPE AIAFRKFTSA
800
801
SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP PPPDCPTSLH
850
851
QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGASHPLLD
900
901
QRQPHYSAFG SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISAEDLLRI
950
951
GVTLAGHQKK ILASVQHMKS QAKPGTPGGT GGPAPQY              
987
 

Show the unformatted sequence.

Checksums:
CRC64:11A004622F194706
MD5:861c0e725f3985dfafb5e602f3449b03

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EphA2_TM 604 - 612 6FNK A 604 - 612 NGL View in InterPro
606 - 612 2VWV A 606 - 612 NGL View in InterPro
2YN8 B 606 - 612 NGL View in InterPro
4BB4 A 606 - 612 NGL View in InterPro
607 - 612 2XVD A 607 - 612 NGL View in InterPro
4AW5 A 83 - 88 NGL View in InterPro
6FNI A 607 - 612 NGL View in InterPro
6FNJ A 607 - 612 NGL View in InterPro
B 607 - 612 NGL View in InterPro
6FNL A 607 - 612 NGL View in InterPro
608 - 612 2VWX A 608 - 612 NGL View in InterPro
2VWY A 608 - 612 NGL View in InterPro
2VWZ A 608 - 612 NGL View in InterPro
2VX0 A 608 - 612 NGL View in InterPro
2VX1 A 608 - 612 NGL View in InterPro
2X9F A 608 - 612 NGL View in InterPro
2YN8 A 608 - 612 NGL View in InterPro
6FNM A 608 - 612 NGL View in InterPro
609 - 612 2VWU A 609 - 612 NGL View in InterPro
2VWW A 609 - 612 NGL View in InterPro
3ZEW A 609 - 612 NGL View in InterPro
B 609 - 612 NGL View in InterPro
Ephrin_lbd 18 - 196 2BBA A 18 - 196 NGL View in InterPro
2HLE A 18 - 196 NGL View in InterPro
fn3 435 - 519 2E7H A 9 - 93 NGL View in InterPro
PK_Tyr_Ser-Thr 615 - 874 2VWU A 615 - 874 NGL View in InterPro
2VWV A 615 - 874 NGL View in InterPro
2VWW A 615 - 874 NGL View in InterPro
2VWX A 615 - 874 NGL View in InterPro
2VWY A 615 - 874 NGL View in InterPro
2VWZ A 615 - 874 NGL View in InterPro
2VX0 A 615 - 874 NGL View in InterPro
2VX1 A 615 - 874 NGL View in InterPro
2X9F A 615 - 874 NGL View in InterPro
2XVD A 615 - 874 NGL View in InterPro
2YN8 A 615 - 874 NGL View in InterPro
B 615 - 874 NGL View in InterPro
3ZEW A 615 - 874 NGL View in InterPro
B 615 - 874 NGL View in InterPro
4AW5 A 91 - 350 NGL View in InterPro
4BB4 A 615 - 874 NGL View in InterPro
6FNI A 615 - 874 NGL View in InterPro
6FNJ A 615 - 874 NGL View in InterPro
B 615 - 874 NGL View in InterPro
6FNK A 615 - 874 NGL View in InterPro
6FNL A 615 - 874 NGL View in InterPro
6FNM A 615 - 874 NGL View in InterPro
SAM_1 908 - 968 2QKQ A 908 - 968 NGL View in InterPro
B 908 - 968 NGL View in InterPro
×

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.