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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: S12A2_HUMAN (P55011)

Summary

This is the summary of UniProt entry S12A2_HUMAN (P55011).

Description: Solute carrier family 12 member 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1212 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 88
low_complexity n/a 24 30
low_complexity n/a 90 113
disorder n/a 97 98
disorder n/a 105 197
low_complexity n/a 147 160
low_complexity n/a 182 198
low_complexity n/a 195 209
Pfam AA_permease_N 202 266
disorder n/a 254 263
disorder n/a 270 271
Pfam AA_permease 290 793
transmembrane n/a 291 311
transmembrane n/a 317 343
low_complexity n/a 321 334
transmembrane n/a 364 388
transmembrane n/a 408 427
transmembrane n/a 436 457
low_complexity n/a 436 444
transmembrane n/a 487 509
transmembrane n/a 521 541
transmembrane n/a 602 622
low_complexity n/a 609 622
transmembrane n/a 655 675
transmembrane n/a 681 699
transmembrane n/a 711 730
transmembrane n/a 736 751
Pfam SLC12 801 1212
disorder n/a 934 940
disorder n/a 967 989
disorder n/a 1119 1120
disorder n/a 1125 1127

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P55011. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVP SVPEDAAPAS
50
51
RDGGGVRDEG PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA
100
101
AAAAAAAGAG AGAKQTPADG EASGESEPAK GSEEAKGRFR VNFVDPAASS
150
151
SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS EGSSLHSGGG GGSGHHQHYY
200
201
YDTHTNTYYL RTFGHNTMDA VPRIDHYRHT AAQLGEKLLR PSLAELHDEL
250
251
EKEPFEDGFA NGEESTPTRD AVVTYTAESK GVVKFGWIKG VLVRCMLNIW
300
301
GVMLFIRLSW IVGQAGIGLS VLVIMMATVV TTITGLSTSA IATNGFVRGG
350
351
GAYYLISRSL GPEFGGAIGL IFAFANAVAV AMYVVGFAET VVELLKEHSI
400
401
LMIDEINDIR IIGAITVVIL LGISVAGMEW EAKAQIVLLV ILLLAIGDFV
450
451
IGTFIPLESK KPKGFFGYKS EIFNENFGPD FREEETFFSV FAIFFPAATG
500
501
ILAGANISGD LADPQSAIPK GTLLAILITT LVYVGIAVSV GSCVVRDATG
550
551
NVNDTIVTEL TNCTSAACKL NFDFSSCESS PCSYGLMNNF QVMSMVSGFT
600
601
PLISAGIFSA TLSSALASLV SAPKIFQALC KDNIYPAFQM FAKGYGKNNE
650
651
PLRGYILTFL IALGFILIAE LNVIAPIISN FFLASYALIN FSVFHASLAK
700
701
SPGWRPAFKY YNMWISLLGA ILCCIVMFVI NWWAALLTYV IVLGLYIYVT
750
751
YKKPDVNWGS STQALTYLNA LQHSIRLSGV EDHVKNFRPQ CLVMTGAPNS
800
801
RPALLHLVHD FTKNVGLMIC GHVHMGPRRQ AMKEMSIDQA KYQRWLIKNK
850
851
MKAFYAPVHA DDLREGAQYL MQAAGLGRMK PNTLVLGFKK DWLQADMRDV
900
901
DMYINLFHDA FDIQYGVVVI RLKEGLDISH LQGQEELLSS QEKSPGTKDV
950
951
VVSVEYSKKS DLDTSKPLSE KPITHKVEEE DGKTATQPLL KKESKGPIVP
1000
1001
LNVADQKLLE ASTQFQKKQG KNTIDVWWLF DDGGLTLLIP YLLTTKKKWK
1050
1051
DCKIRVFIGG KINRIDHDRR AMATLLSKFR IDFSDIMVLG DINTKPKKEN
1100
1101
IIAFEEIIEP YRLHEDDKEQ DIADKMKEDE PWRITDNELE LYKTKTYRQI
1150
1151
RLNELLKEHS STANIIVMSL PVARKGAVSS ALYMAWLEAL SKDLPPILLV
1200
1201
RGNHQSVLTF YS                                         
1212
 

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Checksums:
CRC64:A6BF174ACCDA2EC1
MD5:ee6c6ee7346eb47bd82076f48c9ea963

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AA_permease 290 - 753 6PZT A 290 - 753 NGL View in InterPro
B 290 - 753 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;