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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HNRPK_HUMAN (P61978)

Summary

This is the summary of UniProt entry HNRPK_HUMAN (P61978).

Description: Heterogeneous nuclear ribonucleoprotein K
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 463 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam ROKNT 1 43
disorder n/a 1 37
Pfam KH_1 44 105
disorder n/a 44 45
disorder n/a 73 76
disorder n/a 116 120
Pfam KH_1 146 211
low_complexity n/a 156 168
disorder n/a 221 222
disorder n/a 247 329
low_complexity n/a 252 279
low_complexity n/a 285 301
low_complexity n/a 307 315
low_complexity n/a 323 335
disorder n/a 331 340
disorder n/a 344 345
disorder n/a 347 361
disorder n/a 363 366
low_complexity n/a 365 381
disorder n/a 370 375
disorder n/a 384 387
Pfam KH_1 389 453
low_complexity n/a 400 414
disorder n/a 414 425
disorder n/a 431 438
low_complexity n/a 434 445

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P61978. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ
50
51
SKNAGAVIGK GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI
100
101
LKKIIPTLEE GLQLPSPTAT SQLPLESDAV ECLNYQHYKG SDFDCELRLL
150
151
IHQSLAGGII GVKGAKIKEL RENTQTTIKL FQECCPHSTD RVVLIGGKPD
200
201
RVVECIKIIL DLISESPIKG RAQPYDPNFY DETYDYGGFT MMFDDRRGRP
250
251
VGFPMRGRGG FDRMPPGRGG RPMPPSRRDY DDMSPRRGPP PPPPGRGGRG
300
301
GSRARNLPLP PPPPPRGGDL MAYDRRGRPG DRYDGMVGFS ADETWDSAID
350
351
TWSPSEWQMA YEPQGGSGYD YSYAGGRGSY GDLGGPIITT QVTIPKDLAG
400
401
SIIGKGGQRI KQIRHESGAS IKIDEPLEGS EDRIITITGT QDQIQNAQYL
450
451
LQNSVKQYSG KFF                                        
463
 

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Checksums:
CRC64:0F70EE169B2A064A
MD5:3e488f6b0fe1f0e10bef73c610406d39

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
KH_1 389 - 453 1J5K A 15 - 79 NGL View in InterPro
1KHM A 15 - 79 NGL View in InterPro
1ZZI A 15 - 79 NGL View in InterPro
B 15 - 79 NGL View in InterPro
1ZZJ A 15 - 79 NGL View in InterPro
B 15 - 79 NGL View in InterPro
C 15 - 79 NGL View in InterPro
1ZZK A 15 - 79 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.