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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MURE_MYCTU (P9WJL3)

Summary

This is the summary of UniProt entry MURE_MYCTU (P9WJL3).

Description: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase {ECO:0000255|HAMAP-Rule:MF_00208}
Source organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (NCBI taxonomy ID 83332)
Length: 535 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 12 22
low_complexity n/a 36 48
disorder n/a 50 55
disorder n/a 57 61
Pfam Mur_ligase 61 139
disorder n/a 63 66
low_complexity n/a 147 161
disorder n/a 150 151
Pfam Mur_ligase_M 151 355
low_complexity n/a 166 179
low_complexity n/a 282 296
disorder n/a 308 314
disorder n/a 371 372
Pfam Mur_ligase_C 374 459
disorder n/a 418 420
disorder n/a 429 431
disorder n/a 450 451
disorder n/a 454 461
disorder n/a 502 504
disorder n/a 508 516
low_complexity n/a 521 535

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P9WJL3. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSSLARGISR RRTEVATQVE AAPTGLRPNA VVGVRLAALA DQVGAALAEG
50
51
PAQRAVTEDR TVTGVTLRAQ DVSPGDLFAA LTGSTTHGAR HVGDAIARGA
100
101
VAVLTDPAGV AEIAGRAAVP VLVHPAPRGV LGGLAATVYG HPSERLTVIG
150
151
ITGTSGKTTT TYLVEAGLRA AGRVAGLIGT IGIRVGGADL PSALTTPEAP
200
201
TLQAMLAAMV ERGVDTVVME VSSHALALGR VDGTRFAVGA FTNLSRDHLD
250
251
FHPSMADYFE AKASLFDPDS ALRARTAVVC IDDDAGRAMA ARAADAITVS
300
301
AADRPAHWRA TDVAPTDAGG QQFTAIDPAG VGHHIGIRLP GRYNVANCLV
350
351
ALAILDTVGV SPEQAVPGLR EIRVPGRLEQ IDRGQGFLAL VDYAHKPEAL
400
401
RSVLTTLAHP DRRLAVVFGA GGDRDPGKRA PMGRIAAQLA DLVVVTDDNP
450
451
RDEDPTAIRR EILAGAAEVG GDAQVVEIAD RRDAIRHAVA WARPGDVVLI
500
501
AGKGHETGQR GGGRVRPFDD RVELAAALEA LERRA                
535
 

Show the unformatted sequence.

Checksums:
CRC64:4EB7D79C6374817E
MD5:7f2ae159845e6afe9451898385739c20

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Mur_ligase 61 - 139 2WTZ A 61 - 139 Show 3D Structure View in InterPro
B 61 - 139 Show 3D Structure View in InterPro
C 61 - 139 Show 3D Structure View in InterPro
D 61 - 139 Show 3D Structure View in InterPro
2XJA A 61 - 139 Show 3D Structure View in InterPro
B 61 - 139 Show 3D Structure View in InterPro
C 61 - 139 Show 3D Structure View in InterPro
D 61 - 139 Show 3D Structure View in InterPro
Mur_ligase_C 374 - 457 2WTZ D 374 - 457 Show 3D Structure View in InterPro
374 - 459 2WTZ A 374 - 459 Show 3D Structure View in InterPro
B 374 - 459 Show 3D Structure View in InterPro
C 374 - 459 Show 3D Structure View in InterPro
2XJA A 374 - 459 Show 3D Structure View in InterPro
B 374 - 459 Show 3D Structure View in InterPro
C 374 - 459 Show 3D Structure View in InterPro
D 374 - 459 Show 3D Structure View in InterPro
Mur_ligase_M 151 - 355 2WTZ A 151 - 355 Show 3D Structure View in InterPro
B 151 - 355 Show 3D Structure View in InterPro
C 151 - 355 Show 3D Structure View in InterPro
D 151 - 355 Show 3D Structure View in InterPro
2XJA A 151 - 355 Show 3D Structure View in InterPro
B 151 - 355 Show 3D Structure View in InterPro
C 151 - 355 Show 3D Structure View in InterPro
D 151 - 355 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;