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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ISPH1_MYCTU (P9WKF9)

Summary

This is the summary of UniProt entry ISPH1_MYCTU (P9WKF9).

Description: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 {ECO:0000255|HAMAP-Rule:MF_00191, ECO:0000303|PubMed:23091471, ECO:0000303|PubMed:26309039}
Source organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (NCBI taxonomy ID 83332)
Length: 329 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam LYTB 20 301
disorder n/a 75 78
low_complexity n/a 81 86
disorder n/a 151 156

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P9WKF9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEVFVGPVA QGYASGEVTV LLASPRSFCA GVERAIETVK RVLDVAEGPV
50
51
YVRKQIVHNT VVVAELRDRG AVFVEDLDEI PDPPPPGAVV VFSAHGVSPA
100
101
VRAGADERGL QVVDATCPLV AKVHAEAARF AARGDTVVFI GHAGHEETEG
150
151
TLGVAPRSTL LVQTPADVAA LNLPEGTQLS YLTQTTLALD ETADVIDALR
200
201
ARFPTLGQPP SEDICYATTN RQRALQSMVG ECDVVLVIGS CNSSNSRRLV
250
251
ELAQRSGTPA YLIDGPDDIE PEWLSSVSTI GVTAGASAPP RLVGQVIDAL
300
301
RGYASITVVE RSIATETVRF GLPKQVRAQ                       
329
 

Show the unformatted sequence.

Checksums:
CRC64:00540C5C87B2AB6B
MD5:8eaea7e6c14f072ad8de09075122d2b5

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;