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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PDE1B_HUMAN (Q01064)

Summary

This is the summary of UniProt entry PDE1B_HUMAN (Q01064).

Description: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B EC=3.1.4.17
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 536 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 20
coiled_coil n/a 39 59
coiled_coil n/a 71 91
Pfam PDEase_I_N 77 137
Pfam PDEase_I 222 450
low_complexity n/a 250 262
disorder n/a 444 469
disorder n/a 473 474
disorder n/a 482 483
disorder n/a 496 536
low_complexity n/a 512 528

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q01064. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MELSPRSPPE MLEESDCPSP LELKSAPSKK MWIKLRSLLR YMVKQLENGE
50
51
INIEELKKNL EYTASLLEAV YIDETRQILD TEDELQELRS DAVPSEVRDW
100
101
LASTFTQQAR AKGRRAEEKP KFRSIVHAVQ AGIFVERMFR RTYTSVGPTY
150
151
STAVLNCLKN LDLWCFDVFS LNQAADDHAL RTIVFELLTR HNLISRFKIP
200
201
TVFLMSFLDA LETGYGKYKN PYHNQIHAAD VTQTVHCFLL RTGMVHCLSE
250
251
IELLAIIFAA AIHDYEHTGT TNSFHIQTKS ECAIVYNDRS VLENHHISSV
300
301
FRLMQDDEMN IFINLTKDEF VELRALVIEM VLATDMSCHF QQVKTMKTAL
350
351
QQLERIDKPK ALSLLLHAAD ISHPTKQWLV HSRWTKALME EFFRQGDKEA
400
401
ELGLPFSPLC DRTSTLVAQS QIGFIDFIVE PTFSVLTDVA EKSVQPLADE
450
451
DSKSKNQPSF QWRQPSLDVE VGDPNPDVVS FRSTWVKRIQ ENKQKWKERA
500
501
ASGITNQMSI DELSPCEEEA PPSPAEDEHN QNGNLD               
536
 

Show the unformatted sequence.

Checksums:
CRC64:D15211AC32C756A4
MD5:5b8da34458173e3f3cd5c0b538008767

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PDEase_I 222 - 444 5UOY A 222 - 444 Show 3D Structure View in InterPro
5UP0 A 222 - 444 Show 3D Structure View in InterPro
222 - 445 1TAZ A 222 - 445 Show 3D Structure View in InterPro
4NPW A 222 - 445 Show 3D Structure View in InterPro
5W6E A 222 - 445 Show 3D Structure View in InterPro
222 - 446 4NPV A 222 - 446 Show 3D Structure View in InterPro
222 - 448 5B25 A 222 - 448 Show 3D Structure View in InterPro
B 222 - 448 Show 3D Structure View in InterPro
C 222 - 448 Show 3D Structure View in InterPro
D 222 - 448 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;