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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GLGB_HUMAN (Q04446)

Summary

This is the summary of UniProt entry GLGB_HUMAN (Q04446).

Description: 1,4-alpha-glucan-branching enzyme
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 702 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 2
Pfam CBM_48 75 161
Pfam Alpha-amylase 220 338
Pfam Alpha-amylase_C 603 698

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q04446. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAPMTPAAR PEDYEAALNA ALADVPELAR LLEIDPYLKP YAVDFQRRYK
50
51
QFSQILKNIG ENEGGIDKFS RGYESFGVHR CADGGLYCKE WAPGAEGVFL
100
101
TGDFNGWNPF SYPYKKLDYG KWELYIPPKQ NKSVLVPHGS KLKVVITSKS
150
151
GEILYRISPW AKYVVREGDN VNYDWIHWDP EHSYEFKHSR PKKPRSLRIY
200
201
ESHVGISSHE GKVASYKHFT CNVLPRIKGL GYNCIQLMAI MEHAYYASFG
250
251
YQITSFFAAS SRYGTPEELQ ELVDTAHSMG IIVLLDVVHS HASKNSADGL
300
301
NMFDGTDSCY FHSGPRGTHD LWDSRLFAYS SWEILRFLLS NIRWWLEEYR
350
351
FDGFRFDGVT SMLYHHHGVG QGFSGDYSEY FGLQVDEDAL TYLMLANHLV
400
401
HTLCPDSITI AEDVSGMPAL CSPISQGGGG FDYRLAMAIP DKWIQLLKEF
450
451
KDEDWNMGDI VYTLTNRRYL EKCIAYAESH DQALVGDKSL AFWLMDAEMY
500
501
TNMSVLTPFT PVIDRGIQLH KMIRLITHGL GGEGYLNFMG NEFGHPEWLD
550
551
FPRKGNNESY HYARRQFHLT DDDLLRYKFL NNFDRDMNRL EERYGWLAAP
600
601
QAYVSEKHEG NKIIAFERAG LLFIFNFHPS KSYTDYRVGT ALPGKFKIVL
650
651
DSDAAEYGGH QRLDHSTDFF SEAFEHNGRP YSLLVYIPSR VALILQNVDL
700
701
PN                                                    
702
 

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Checksums:
CRC64:DEF534C821A72323
MD5:d5c85b7319aca904d89320ea1b9f735f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Alpha-amylase 220 - 338 4BZY A 220 - 338 NGL View in InterPro
B 220 - 338 NGL View in InterPro
C 220 - 338 NGL View in InterPro
5CLT A 220 - 338 NGL View in InterPro
B 220 - 338 NGL View in InterPro
C 220 - 338 NGL View in InterPro
5CLW A 220 - 338 NGL View in InterPro
B 220 - 338 NGL View in InterPro
C 220 - 338 NGL View in InterPro
Alpha-amylase_C 603 - 698 4BZY A 603 - 698 NGL View in InterPro
B 603 - 698 NGL View in InterPro
C 603 - 698 NGL View in InterPro
5CLT A 603 - 698 NGL View in InterPro
B 603 - 698 NGL View in InterPro
C 603 - 698 NGL View in InterPro
5CLW A 603 - 698 NGL View in InterPro
B 603 - 698 NGL View in InterPro
C 603 - 698 NGL View in InterPro
CBM_48 75 - 161 4BZY A 75 - 161 NGL View in InterPro
B 75 - 161 NGL View in InterPro
C 75 - 161 NGL View in InterPro
5CLT A 75 - 161 NGL View in InterPro
B 75 - 161 NGL View in InterPro
C 75 - 161 NGL View in InterPro
5CLW A 75 - 161 NGL View in InterPro
B 75 - 161 NGL View in InterPro
C 75 - 161 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;