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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PCDH1_HUMAN (Q08174)

Summary

This is the summary of UniProt entry PCDH1_HUMAN (Q08174).

Description: Protocadherin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1060 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 4
sig_p n/a 1 57
disorder n/a 24 31
low_complexity n/a 37 54
Pfam Cadherin_2 59 142
disorder n/a 59 65
disorder n/a 74 75
disorder n/a 110 115
disorder n/a 119 122
disorder n/a 154 160
disorder n/a 169 170
Pfam Cadherin 173 271
disorder n/a 188 190
disorder n/a 198 207
disorder n/a 215 222
disorder n/a 228 236
disorder n/a 247 254
disorder n/a 262 268
disorder n/a 276 288
Pfam Cadherin 285 378
disorder n/a 290 293
disorder n/a 296 307
disorder n/a 311 317
disorder n/a 356 357
disorder n/a 368 377
disorder n/a 388 389
Pfam Cadherin 401 497
disorder n/a 415 417
disorder n/a 444 445
disorder n/a 451 454
disorder n/a 456 457
disorder n/a 489 494
disorder n/a 510 513
Pfam Cadherin 511 603
disorder n/a 521 530
disorder n/a 537 543
disorder n/a 556 557
disorder n/a 565 571
disorder n/a 577 584
Pfam Cadherin 617 706
disorder n/a 632 635
disorder n/a 644 648
disorder n/a 684 685
disorder n/a 712 714
disorder n/a 716 721
disorder n/a 723 732
Pfam Cadherin 727 813
disorder n/a 737 738
Pfam Protocadherin 815 1029
disorder n/a 837 842
transmembrane n/a 853 874
low_complexity n/a 853 874
disorder n/a 884 885
disorder n/a 887 946
low_complexity n/a 899 924
disorder n/a 948 1047
low_complexity n/a 973 986

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q08174. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDSGAGGRRC PEAALLILGP PRMEHLRHSP GPGGQRLLLP SMLLALLLLL
50
51
APSPGHATRV VYKVPEEQPP NTLIGSLAAD YGFPDVGHLY KLEVGAPYLR
100
101
VDGKTGDIFT TETSIDREGL RECQNQLPGD PCILEFEVSI TDLVQNGSPR
150
151
LLEGQIEVQD INDNTPNFAS PVITLAIPEN TNIGSLFPIP LASDRDAGPN
200
201
GVASYELQAG PEAQELFGLQ VAEDQEEKQP QLIVMGNLDR ERWDSYDLTI
250
251
KVQDGGSPPR ASSALLRVTV LDTNDNAPKF ERPSYEAELS ENSPIGHSVI
300
301
QVKANDSDQG ANAEIEYTFH QAPEVVRRLL RLDRNTGLIT VQGPVDREDL
350
351
STLRFSVLAK DRGTNPKSAR AQVVVTVKDM NDNAPTIEIR GIGLVTHQDG
400
401
MANISEDVAE ETAVALVQVS DRDEGENAAV TCVVAGDVPF QLRQASETGS
450
451
DSKKKYFLQT TTPLDYEKVK DYTIEIVAVD SGNPPLSSTN SLKVQVVDVN
500
501
DNAPVFTQSV TEVAFPENNK PGEVIAEITA SDADSGSNAE LVYSLEPEPA
550
551
AKGLFTISPE TGEIQVKTSL DREQRESYEL KVVAADRGSP SLQGTATVLV
600
601
NVLDCNDNDP KFMLSGYNFS VMENMPALSP VGMVTVIDGD KGENAQVQLS
650
651
VEQDNGDFVI QNGTGTILSS LSFDREQQST YTFQLKAVDG GVPPRSAYVG
700
701
VTINVLDEND NAPYITAPSN TSHKLLTPQT RLGETVSQVA AEDFDSGVNA
750
751
ELIYSIAGGN PYGLFQIGSH SGAITLEKEI ERRHHGLHRL VVKVSDRGKP
800
801
PRYGTALVHL YVNETLANRT LLETLLGHSL DTPLDIDIAG DPEYERSKQR
850
851
GNILFGVVAG VVAVALLIAL AVLVRYCRQR EAKSGYQAGK KETKDLYAPK
900
901
PSGKASKGNK SKGKKSKSPK PVKPVEDEDE AGLQKSLKFN LMSDAPGDSP
950
951
RIHLPLNYPP GSPDLGRHYR SNSPLPSIQL QPQSPSASKK HQVVQDLPPA
1000
1001
NTFVGTGDTT STGSEQYSDY SYRTNPPKYP SKQVGQPFQL STPQPLPHPY
1050
1051
HGAIWTEVWE                                            
1060
 

Show the unformatted sequence.

Checksums:
CRC64:0F4F24F3EE607D04
MD5:4cb84b5171e5e6571a8a374d1786a72a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cadherin 173 - 271 6BX7 A 116 - 214 NGL View in InterPro
6MGA A 116 - 214 NGL View in InterPro
6VFP A 116 - 214 NGL View in InterPro
285 - 378 6BX7 A 228 - 321 NGL View in InterPro
6MGA A 228 - 321 NGL View in InterPro
6PIM A 228 - 321 NGL View in InterPro
6VFP A 228 - 321 NGL View in InterPro
401 - 496 6MGA A 344 - 439 NGL View in InterPro
401 - 497 6BX7 A 344 - 440 NGL View in InterPro
6VFP A 344 - 440 NGL View in InterPro
407 - 495 6PIM A 350 - 438 NGL View in InterPro
Cadherin_2 59 - 142 6VFP A 2 - 85 NGL View in InterPro
60 - 142 6BX7 A 3 - 85 NGL View in InterPro
6MGA A 3 - 85 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;