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36  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ITK_HUMAN (Q08881)

Summary

This is the summary of UniProt entry ITK_HUMAN (Q08881).

Description: Tyrosine-protein kinase ITK/TSK EC=2.7.10.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 620 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam PH 5 111
Pfam BTK 119 148
disorder n/a 150 166
Pfam SH3_1 177 223
disorder n/a 221 222
Pfam SH2 239 323
Pfam PK_Tyr_Ser-Thr 363 612

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q08881. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT
50
51
LKGSIELSRI KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ
100
101
RWVLALKEET RNNNSLVPKY HPNFWMDGKW RCCSQLEKLA TGCAQYDPTK
150
151
NASKKPLPPT PEDNRRPLWE PEETVVIALY DYQTNDPQEL ALRRNEEYCL
200
201
LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY NKSISRDKAE
250
251
KLLLDTGKEG AFMVRDSRTA GTYTVSVFTK AVVSENNPCI KHYHIKETND
300
301
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG
350
351
LRYGKWVIDP SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIREGAMSE
400
401
EDFIEEAEVM MKLSHPKLVQ LYGVCLEQAP ICLVFEFMEH GCLSDYLRTQ
450
451
RGLFAAETLL GMCLDVCEGM AYLEEACVIH RDLAARNCLV GENQVIKVSD
500
501
FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD VWSFGVLMWE
550
551
VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASTHVYQI MNHCWKERPE
600
601
DRPAFSRLLR QLAEIAESGL                                 
620
 

Show the unformatted sequence.

Checksums:
CRC64:DAE396BD2309319D
MD5:bc739105238eb6e59a00ef883d06430b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BTK 119 - 148 2E6I A 14 - 43 NGL View in InterPro
PK_Tyr_Ser-Thr 363 - 612 1SM2 A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
1SNU A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
1SNX A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
3MIY A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
3MJ1 A 363 - 612 NGL View in InterPro
3MJ2 A 363 - 612 NGL View in InterPro
3QGW A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
3QGY A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
3T9T A 363 - 612 NGL View in InterPro
3V5J A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
3V5L A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
C 363 - 612 NGL View in InterPro
D 363 - 612 NGL View in InterPro
3V8T A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
3V8W A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4HCT A 363 - 612 NGL View in InterPro
4HCU A 363 - 612 NGL View in InterPro
4HCV A 363 - 612 NGL View in InterPro
4KIO A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
C 363 - 612 NGL View in InterPro
D 363 - 612 NGL View in InterPro
4L7S A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4M0Y A 363 - 612 NGL View in InterPro
4M0Z A 363 - 612 NGL View in InterPro
4M12 A 363 - 612 NGL View in InterPro
4M13 A 363 - 612 NGL View in InterPro
4M14 A 363 - 612 NGL View in InterPro
4M15 A 363 - 612 NGL View in InterPro
4MF0 A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4MF1 A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4PP9 A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4PPA A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4PPB A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4PPC A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4PQN A 363 - 612 NGL View in InterPro
4QD6 A 363 - 612 NGL View in InterPro
B 363 - 612 NGL View in InterPro
4RFM A 363 - 612 NGL View in InterPro
SH3_1 177 - 223 2LMJ A 12 - 58 NGL View in InterPro
2YUQ A 23 - 69 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;