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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NR1H3_HUMAN (Q13133)

Summary

This is the summary of UniProt entry NR1H3_HUMAN (Q13133).

Description: Oxysterols receptor LXR-alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 447 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 3 9
disorder n/a 12 27
low_complexity n/a 24 37
disorder n/a 31 44
disorder n/a 49 55
disorder n/a 57 58
disorder n/a 61 88
Pfam zf-C4 96 165
coiled_coil n/a 169 189
disorder n/a 179 205
low_complexity n/a 197 211
disorder n/a 235 250
Pfam Hormone_recep 243 431

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13133. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA
50
51
GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV
100
101
CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC
150
151
QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP
200
201
QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM APDPHSREAR
250
251
QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL
300
301
ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ
350
351
LNDAEFALLI AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD
400
401
RLMFPRMLMK LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE   
447
 

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Checksums:
CRC64:0D27B237440F8C9C
MD5:278fe1fcc095ca77b9f96630d6ee943b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Hormone_recep 244 - 431 3IPU A 244 - 431 NGL View in InterPro
5AVI A 244 - 431 NGL View in InterPro
246 - 431 3IPS A 246 - 431 NGL View in InterPro
B 246 - 431 NGL View in InterPro
3IPU B 246 - 431 NGL View in InterPro
5AVI C 246 - 431 NGL View in InterPro
5HJS A 82 - 267 NGL View in InterPro
B 82 - 267 NGL View in InterPro
247 - 431 5AVL A 247 - 431 NGL View in InterPro
248 - 431 1UHL B 248 - 431 NGL View in InterPro
3IPQ A 248 - 431 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;