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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SEPT6_HUMAN (Q14141)

Summary

This is the summary of UniProt entry SEPT6_HUMAN (Q14141).

Description: Septin-6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 434 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Septin 39 312
disorder n/a 73 76
disorder n/a 78 81
disorder n/a 311 323
coiled_coil n/a 321 341
disorder n/a 331 333
disorder n/a 343 352
coiled_coil n/a 343 399
low_complexity n/a 351 367
disorder n/a 358 359
disorder n/a 361 362
disorder n/a 368 370
low_complexity n/a 371 392
disorder n/a 375 377
disorder n/a 379 394
disorder n/a 397 434
low_complexity n/a 407 417

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14141. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAATDIARQV GEGCRTVPLA GHVGFDSLPD QLVNKSVSQG FCFNILCVGE
50
51
TGLGKSTLMD TLFNTKFEGE PATHTQPGVQ LQSNTYDLQE SNVRLKLTIV
100
101
STVGFGDQIN KEDSYKPIVE FIDAQFEAYL QEELKIRRVL HTYHDSRIHV
150
151
CLYFIAPTGH SLKSLDLVTM KKLDSKVNII PIIAKADAIS KSELTKFKIK
200
201
ITSELVSNGV QIYQFPTDDE SVAEINGTMN AHLPFAVIGS TEELKIGNKM
250
251
MRARQYPWGT VQVENEAHCD FVKLREMLIR VNMEDLREQT HTRHYELYRR
300
301
CKLEEMGFKD TDPDSKPFSL QETYEAKRNE FLGELQKKEE EMRQMFVQRV
350
351
KEKEAELKEA EKELHEKFDR LKKLHQDEKK KLEDKKKSLD DEVNAFKQRK
400
401
TAAELLQSQG SQAGGSQTLK RDKEKKNNPW LCTE                 
434
 

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Checksums:
CRC64:E684AE6A93B32362
MD5:ec0337285a3e2a9349f4a6a456e394eb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Septin 40 - 307 2QAG B 40 - 307 NGL View in InterPro
41 - 305 6UPA B 41 - 305 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.