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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BECN1_HUMAN (Q14457)

Summary

This is the summary of UniProt entry BECN1_HUMAN (Q14457).

Description: Beclin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 450 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 9
disorder n/a 11 13
disorder n/a 44 87
low_complexity n/a 55 67
disorder n/a 93 104
Pfam BH3 105 129
disorder n/a 108 111
disorder n/a 134 140
Pfam APG6_N 135 261
low_complexity n/a 141 152
coiled_coil n/a 145 267
disorder n/a 147 152
disorder n/a 176 177
low_complexity n/a 178 194
disorder n/a 179 183
disorder n/a 219 221
disorder n/a 223 224
Pfam APG6 264 445

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14457. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA
50
51
QAKPGETQEE ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI
100
101
GEASDGGTME NLSRRLKVTG DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT
150
151
QLNVTENECQ NYKRCLEILE QMNEDDSEQL QMELKELALE EERLIQELED
200
201
VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ LELDDELKSV
250
251
ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW
300
301
NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP
350
351
LYCSGGLRFF WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK
400
401
GKIEDTGGSG GSYSIKTQFN SEEQWTKALK FMLTNLKWGL AWVSSQFYNK
450
451
                                                      
450
 

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Checksums:
CRC64:ABF0C2DD7087473C
MD5:3aaba50d9a4036d90b9a90a94fa12df4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
APG6 264 - 265 5HHE A 264 - 265 NGL View in InterPro
D 264 - 265 NGL View in InterPro
264 - 445 4DDP A 264 - 445 NGL View in InterPro
APG6_N 157 - 171 5EFM A 157 - 171 NGL View in InterPro
175 - 261 5HHE A 175 - 261 NGL View in InterPro
D 175 - 261 NGL View in InterPro
248 - 261 4DDP A 248 - 261 NGL View in InterPro
BH3 105 - 128 3DVU D 105 - 128 NGL View in InterPro
106 - 128 2PON A 21 - 43 NGL View in InterPro
106 - 129 3DVU C 106 - 129 NGL View in InterPro
107 - 127 4MI8 D 107 - 127 NGL View in InterPro
5VAY G 107 - 127 NGL View in InterPro
6DCN C 107 - 127 NGL View in InterPro
D 107 - 127 NGL View in InterPro
107 - 128 2P1L B 107 - 128 NGL View in InterPro
D 107 - 128 NGL View in InterPro
F 107 - 128 NGL View in InterPro
H 107 - 128 NGL View in InterPro
107 - 129 5VAX G 107 - 129 NGL View in InterPro
108 - 127 4MI8 C 108 - 127 NGL View in InterPro
5VAU G 108 - 127 NGL View in InterPro
H 108 - 127 NGL View in InterPro
5VAY H 108 - 127 NGL View in InterPro
6DCO C 108 - 127 NGL View in InterPro
108 - 128 5VAU F 108 - 128 NGL View in InterPro
5VAX F 108 - 128 NGL View in InterPro
H 108 - 128 NGL View in InterPro
5VAY E 108 - 128 NGL View in InterPro
F 108 - 128 NGL View in InterPro
6DCO D 108 - 128 NGL View in InterPro
108 - 129 5VAX E 108 - 129 NGL View in InterPro
109 - 128 5VAU E 109 - 128 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.