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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN5A_HUMAN (Q14524)

Summary

This is the summary of UniProt entry SCN5A_HUMAN (Q14524).

Description: Sodium channel protein type 5 subunit alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2016 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 27 57
disorder n/a 61 63
transmembrane n/a 127 149
Pfam Ion_trans 130 423
transmembrane n/a 198 218
transmembrane n/a 230 247
transmembrane n/a 253 273
transmembrane n/a 388 416
coiled_coil n/a 413 451
disorder n/a 424 429
disorder n/a 435 436
disorder n/a 461 593
low_complexity n/a 474 484
Pfam Na_trans_cytopl 507 667
disorder n/a 598 651
Pfam Ion_trans 716 948
transmembrane n/a 721 739
transmembrane n/a 751 769
transmembrane n/a 781 798
low_complexity n/a 804 816
transmembrane n/a 838 861
low_complexity n/a 844 856
transmembrane n/a 881 902
transmembrane n/a 914 939
low_complexity n/a 927 944
Pfam Na_trans_assoc 953 1200
disorder n/a 996 997
disorder n/a 1001 1156
low_complexity n/a 1007 1026
low_complexity n/a 1029 1044
low_complexity n/a 1053 1064
low_complexity n/a 1070 1080
low_complexity n/a 1096 1113
Pfam Ion_trans 1204 1481
transmembrane n/a 1205 1224
transmembrane n/a 1245 1261
transmembrane n/a 1273 1294
low_complexity n/a 1301 1316
transmembrane n/a 1322 1348
transmembrane n/a 1444 1470
low_complexity n/a 1445 1460
Pfam Ion_trans 1527 1783
transmembrane n/a 1529 1547
transmembrane n/a 1559 1581
transmembrane n/a 1593 1609
transmembrane n/a 1615 1634
low_complexity n/a 1625 1644
transmembrane n/a 1646 1674
disorder n/a 1732 1734
transmembrane n/a 1749 1772
disorder n/a 1932 1935
disorder n/a 1937 1940
disorder n/a 1943 1944
low_complexity n/a 1957 1979
disorder n/a 1960 2016

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14524. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSTTLQ ESREGLPEEE
50
51
APRPQLDLQA SKKLPDLYGN PPQELIGEPL EDLDPFYSTQ KTFIVLNKGK
100
101
TIFRFSATNA LYVLSPFHPI RRAAVKILVH SLFNMLIMCT ILTNCVFMAQ
150
151
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV
200
201
IIMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL
250
251
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNGT NGSVEADGLV
300
301
WESLDLYLSD PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH
350
351
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG
400
401
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI
450
451
RGVDTVSRSS LEMSPLAPVN SHERRSKRRK RMSSGTEECG EDRLPKSDSE
500
501
DGPRAMNHLS LTRGLSRTSM KPRSSRGSIF TFRRRDLGSE ADFADDENST
550
551
AGESESHHTS LLVPWPLRRT SAQGQPSPGT SAPGHALHGK KNSTVDCNGV
600
601
VSLLGAGDPE ATSPGSHLLR PVMLEHPPDT TTPSEEPGGP QMLTSQAPCV
650
651
DGFEEPGARQ RALSAVSVLT SALEELEESR HKCPPCWNRL AQRYLIWECC
700
701
PLWMSIKQGV KLVVMDPFTD LTITMCIVLN TLFMALEHYN MTSEFEEMLQ
750
751
VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG WNIFDSIIVI LSLMELGLSR
800
801
MSNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV
850
851
FIFAVVGMQL FGKNYSELRD SDSGLLPRWH MMDFFHAFLI IFRILCGEWI
900
901
ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP
950
951
DEDREMNNLQ LALARIQRGL RFVKRTTWDF CCGLLRQRPQ KPAALAAQGQ
1000
1001
LPSCIATPYS PPPPETEKVP PTRKETRFEE GEQPGQGTPG DPEPVCVPIA
1050
1051
VAESDTDDQE EDEENSLGTE EESSKQQESQ PVSGGPEAPP DSRTWSQVSA
1100
1101
TASSEAEASA SQADWRQQWK AEPQAPGCGE TPEDSCSEGS TADMTNTAEL
1150
1151
LEQIPDLGQD VKDPEDCFTE GCVRRCPCCA VDTTQAPGKV WWRLRKTCYH
1200
1201
IVEHSWFETF IIFMILLSSG ALAFEDIYLE ERKTIKVLLE YADKMFTYVF
1250
1251
VLEMLLKWVA YGFKKYFTNA WCWLDFLIVD VSLVSLVANT LGFAEMGPIK
1300
1301
SLRTLRALRP LRALSRFEGM RVVVNALVGA IPSIMNVLLV CLIFWLIFSI
1350
1351
MGVNLFAGKF GRCINQTEGD LPLNYTIVNN KSQCESLNLT GELYWTKVKV
1400
1401
NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRGYEEQPQW EYNLYMYIYF
1450
1451
VIFIIFGSFF TLNLFIGVII DNFNQQKKKL GGQDIFMTEE QKKYYNAMKK
1500
1501
LGSKKPQKPI PRPLNKYQGF IFDIVTKQAF DVTIMFLICL NMVTMMVETD
1550
1551
DQSPEKINIL AKINLLFVAI FTGECIVKLA ALRHYYFTNS WNIFDFVVVI
1600
1601
LSIVGTVLSD IIQKYFFSPT LFRVIRLARI GRILRLIRGA KGIRTLLFAL
1650
1651
MMSLPALFNI GLLLFLVMFI YSIFGMANFA YVKWEAGIDD MFNFQTFANS
1700
1701
MLCLFQITTS AGWDGLLSPI LNTGPPYCDP TLPNSNGSRG DCGSPAVGIL
1750
1751
FFTTYIIISF LIVVNMYIAI ILENFSVATE ESTEPLSEDD FDMFYEIWEK
1800
1801
FDPEATQFIE YSVLSDFADA LSEPLRIAKP NQISLINMDL PMVSGDRIHC
1850
1851
MDILFAFTKR VLGESGEMDA LKIQMEEKFM AANPSKISYE PITTTLRRKH
1900
1901
EEVSAMVIQR AFRRHLLQRS LKHASFLFRQ QAGSGLSEED APEREGLIAY
1950
1951
VMSENFSRPL GPPSSSSISS TSFPPSYDSV TRATSDNLQV RGSDYSHSED
2000
2001
LADFPPSPDR DRESIV                                     
2016
 

Show the unformatted sequence.

Checksums:
CRC64:841E3A365931190B
MD5:938f32426a694c27fbc6087aa15dd942

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ion_trans 1204 - 1481 6LQA B 1204 - 1481 Show 3D Structure View in InterPro
7DTC A 1204 - 1481 Show 3D Structure View in InterPro
130 - 423 6LQA B 130 - 423 Show 3D Structure View in InterPro
7DTC A 130 - 423 Show 3D Structure View in InterPro
1527 - 1781 6LQA B 1527 - 1781 Show 3D Structure View in InterPro
7DTC A 1527 - 1781 Show 3D Structure View in InterPro
1597 - 1633 7L83 A 1 - 37 Show 3D Structure View in InterPro
1773 - 1783 2KBI A 1773 - 1783 Show 3D Structure View in InterPro
1776 - 1783 4DCK A 1776 - 1783 Show 3D Structure View in InterPro
4OVN J 1776 - 1783 Show 3D Structure View in InterPro
1777 - 1783 4OVN H 1777 - 1783 Show 3D Structure View in InterPro
1782 - 1783 4OVN F 1782 - 1783 Show 3D Structure View in InterPro
716 - 944 6LQA B 716 - 944 Show 3D Structure View in InterPro
7DTC A 716 - 944 Show 3D Structure View in InterPro
Na_trans_assoc 1188 - 1200 6LQA B 1188 - 1200 Show 3D Structure View in InterPro
7DTC A 1188 - 1200 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;