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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NMDE3_HUMAN (Q14957)

Summary

This is the summary of UniProt entry NMDE3_HUMAN (Q14957).

Description: Glutamate receptor ionotropic, NMDA 2C
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1233 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 19
disorder n/a 32 33
Pfam ANF_receptor 69 288
disorder n/a 315 319
Pfam Lig_chan-Glu_bd 401 539
disorder n/a 426 429
Pfam Lig_chan 552 826
transmembrane n/a 554 574
transmembrane n/a 595 615
transmembrane n/a 627 652
disorder n/a 679 680
transmembrane n/a 816 835
low_complexity n/a 821 832
Pfam NMDAR2_C 837 923
transmembrane n/a 855 874
disorder n/a 877 887
disorder n/a 905 911
disorder n/a 914 999
low_complexity n/a 924 944
low_complexity n/a 940 963
low_complexity n/a 975 987
disorder n/a 1002 1003
disorder n/a 1005 1008
disorder n/a 1010 1017
disorder n/a 1026 1030
low_complexity n/a 1041 1060
disorder n/a 1066 1067
disorder n/a 1082 1084
low_complexity n/a 1183 1197

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14957. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL
50
51
TPQSFLDLPL EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD
100
101
TEAVAQILDF ISSQTHVPIL SISGGSAVVL TPKEPGSAFL QLGVSLEQQL
150
151
QVLFKVLEEY DWSAFAVITS LHPGHALFLE GVRAVADASH VSWRLLDVVT
200
201
LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA AQAGLVGPGH
250
251
VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA
300
301
HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG
350
351
GYLVQPTMVV IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS
400
401
RHLTVATLEE RPFVIVESPD PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT
450
451
KLCCKGFCID ILKKLARVVK FSYDLYLVTN GKHGKRVRGV WNGMIGEVYY
500
501
KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG TVSPSAFLEP
550
551
YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG
600
601
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF
650
651
MIQEQYIDTV SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH
700
701
THMVKFNQRS VEDALTSLKM GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS
750
751
GKVFATTGYG IAMQKDSHWK RAIDLALLQF LGDGETQKLE TVWLSGICQN
800
801
EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY WKLRHSVPNS
850
851
SQLDFLLAFS RGIYSCFSGV QSLASPPRQA SPDLTASSAQ ASVLKMLQAA
900
901
RDMVTTAGVS SSLDRATRTI ENWGGGRRAP PPSPCPTPRS GPSPCLPTPD
950
951
PPPEPSPTGW GPPDGGRAAL VRRAPQPPGR PPTPGPPLSD VSRVSRRPAW
1000
1001
EARWPVRTGH CGRHLSASER PLSPARCHYS SFPRADRSGR PFLPLFPELE
1050
1051
DLPLLGPEQL ARREALLHAA WARGSRPRHA SLPSSVAEAF ARPSSLPAGC
1100
1101
TGPACARPDG HSACRRLAQA QSMCLPIYRE ACQEGEQAGA PAWQHRQHVC
1150
1151
LHAHAHLPFC WGAVCPHLPP CASHGSWLSG AWGPLGHRGR TLGLGTGYRD
1200
1201
SGGLDEISRV ARGTQGFPGP CTWRRISSLE SEV                  
1233
 

Show the unformatted sequence.

Checksums:
CRC64:7B1F2F7995C0D689
MD5:d0c66e493531f5be2fe50c949600cf67

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;