Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NUMA1_HUMAN (Q14980)

Summary

This is the summary of UniProt entry NUMA1_HUMAN (Q14980).

Description: Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2115 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 146 148
disorder n/a 161 169
low_complexity n/a 189 200
disorder n/a 193 214
disorder n/a 216 223
coiled_coil n/a 216 250
disorder n/a 225 232
disorder n/a 234 239
disorder n/a 244 246
disorder n/a 248 249
disorder n/a 262 287
coiled_coil n/a 278 319
disorder n/a 289 290
disorder n/a 292 318
coiled_coil n/a 327 400
disorder n/a 338 358
disorder n/a 369 370
disorder n/a 387 412
low_complexity n/a 387 398
coiled_coil n/a 415 449
disorder n/a 426 427
disorder n/a 429 439
disorder n/a 443 456
disorder n/a 462 463
coiled_coil n/a 468 491
disorder n/a 478 502
coiled_coil n/a 500 777
disorder n/a 507 509
disorder n/a 511 512
disorder n/a 514 516
disorder n/a 518 528
low_complexity n/a 521 549
disorder n/a 532 558
low_complexity n/a 554 569
disorder n/a 560 561
disorder n/a 564 605
low_complexity n/a 585 603
low_complexity n/a 601 618
disorder n/a 630 646
disorder n/a 656 664
low_complexity n/a 660 680
disorder n/a 666 681
disorder n/a 684 699
disorder n/a 705 706
disorder n/a 711 712
disorder n/a 715 727
disorder n/a 729 734
disorder n/a 746 778
low_complexity n/a 752 770
disorder n/a 780 801
coiled_coil n/a 789 823
disorder n/a 818 819
disorder n/a 822 826
disorder n/a 828 830
coiled_coil n/a 828 862
disorder n/a 842 844
disorder n/a 846 847
disorder n/a 849 865
disorder n/a 867 872
coiled_coil n/a 867 922
disorder n/a 879 881
disorder n/a 896 911
disorder n/a 916 959
disorder n/a 962 1026
coiled_coil n/a 967 1040
low_complexity n/a 992 1005
low_complexity n/a 1015 1034
disorder n/a 1028 1033
disorder n/a 1049 1071
coiled_coil n/a 1066 1100
disorder n/a 1088 1187
low_complexity n/a 1088 1100
low_complexity n/a 1102 1113
coiled_coil n/a 1122 1156
low_complexity n/a 1133 1142
low_complexity n/a 1145 1165
coiled_coil n/a 1171 1205
disorder n/a 1189 1201
disorder n/a 1203 1218
coiled_coil n/a 1213 1275
disorder n/a 1220 1225
low_complexity n/a 1225 1237
disorder n/a 1238 1239
disorder n/a 1248 1257
disorder n/a 1266 1272
low_complexity n/a 1274 1293
disorder n/a 1276 1278
disorder n/a 1280 1299
coiled_coil n/a 1280 1335
disorder n/a 1301 1303
disorder n/a 1305 1320
disorder n/a 1323 1324
coiled_coil n/a 1367 1405
low_complexity n/a 1368 1378
disorder n/a 1371 1390
low_complexity n/a 1390 1409
coiled_coil n/a 1409 1443
disorder n/a 1423 1425
disorder n/a 1427 1428
disorder n/a 1451 1452
coiled_coil n/a 1462 1511
disorder n/a 1491 1496
coiled_coil n/a 1516 1543
low_complexity n/a 1521 1531
disorder n/a 1553 1560
disorder n/a 1562 1563
low_complexity n/a 1563 1578
disorder n/a 1565 1581
coiled_coil n/a 1572 1693
low_complexity n/a 1576 1587
low_complexity n/a 1581 1602
disorder n/a 1583 1595
disorder n/a 1597 1598
disorder n/a 1603 1682
low_complexity n/a 1624 1644
disorder n/a 1684 1685
disorder n/a 1687 1688
disorder n/a 1694 1695
disorder n/a 1698 1725
low_complexity n/a 1718 1728
disorder n/a 1733 1764
disorder n/a 1784 1786
disorder n/a 1789 1795
disorder n/a 1797 1805
disorder n/a 1807 1823
disorder n/a 1826 1861
disorder n/a 1863 1864
disorder n/a 1868 1911
disorder n/a 1913 1926
disorder n/a 1931 1939
disorder n/a 1941 2115
low_complexity n/a 2084 2109

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14980. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTLHATRGAA LLSWVNSLHV ADPVEAVLQL QDCSIFIKII DRIHGTEEGQ
50
51
QILKQPVSER LDFVCSFLQK NRKHPSSPEC LVSAQKVLEG SELELAKMTM
100
101
LLLYHSTMSS KSPRDWEQFE YKIQAELAVI LKFVLDHEDG LNLNEDLENF
150
151
LQKAPVPSTC SSTFPEELSP PSHQAKREIR FLELQKVASS SSGNNFLSGS
200
201
PASPMGDILQ TPQFQMRRLK KQLADERSNR DELELELAEN RKLLTEKDAQ
250
251
IAMMQQRIDR LALLNEKQAA SPLEPKELEE LRDKNESLTM RLHETLKQCQ
300
301
DLKTEKSQMD RKINQLSEEN GDLSFKLREF ASHLQQLQDA LNELTEEHSK
350
351
ATQEWLEKQA QLEKELSAAL QDKKCLEEKN EILQGKLSQL EEHLSQLQDN
400
401
PPQEKGEVLG DVLQLETLKQ EAATLAANNT QLQARVEMLE TERGQQEAKL
450
451
LAERGHFEEE KQQLSSLITD LQSSISNLSQ AKEELEQASQ AHGARLTAQV
500
501
ASLTSELTTL NATIQQQDQE LAGLKQQAKE KQAQLAQTLQ QQEQASQGLR
550
551
HQVEQLSSSL KQKEQQLKEV AEKQEATRQD HAQQLATAAE EREASLRERD
600
601
AALKQLEALE KEKAAKLEIL QQQLQVANEA RDSAQTSVTQ AQREKAELSR
650
651
KVEELQACVE TARQEQHEAQ AQVAELELQL RSEQQKATEK ERVAQEKDQL
700
701
QEQLQALKES LKVTKGSLEE EKRRAADALE EQQRCISELK AETRSLVEQH
750
751
KRERKELEEE RAGRKGLEAR LQQLGEAHQA ETEVLRRELA EAMAAQHTAE
800
801
SECEQLVKEV AAWRERYEDS QQEEAQYGAM FQEQLMTLKE ECEKARQELQ
850
851
EAKEKVAGIE SHSELQISRQ QNELAELHAN LARALQQVQE KEVRAQKLAD
900
901
DLSTLQEKMA ATSKEVARLE TLVRKAGEQQ ETASRELVKE PARAGDRQPE
950
951
WLEEQQGRQF CSTQAALQAM EREAEQMGNE LERLRAALME SQGQQQEERG
1000
1001
QQEREVARLT QERGRAQADL ALEKAARAEL EMRLQNALNE QRVEFATLQE
1050
1051
ALAHALTEKE GKDQELAKLR GLEAAQIKEL EELRQTVKQL KEQLAKKEKE
1100
1101
HASGSGAQSE AAGRTEPTGP KLEALRAEVS KLEQQCQKQQ EQADSLERSL
1150
1151
EAERASRAER DSALETLQGQ LEEKAQELGH SQSALASAQR ELAAFRTKVQ
1200
1201
DHSKAEDEWK AQVARGRQEA ERKNSLISSL EEEVSILNRQ VLEKEGESKE
1250
1251
LKRLVMAESE KSQKLEERLR LLQAETASNS ARAAERSSAL REEVQSLREE
1300
1301
AEKQRVASEN LRQELTSQAE RAEELGQELK AWQEKFFQKE QALSTLQLEH
1350
1351
TSTQALVSEL LPAKHLCQQL QAEQAAAEKR HREELEQSKQ AAGGLRAELL
1400
1401
RAQRELGELI PLRQKVAEQE RTAQQLRAEK ASYAEQLSML KKAHGLLAEE
1450
1451
NRGLGERANL GRQFLEVELD QAREKYVQEL AAVRADAETR LAEVQREAQS
1500
1501
TARELEVMTA KYEGAKVKVL EERQRFQEER QKLTAQVEQL EVFQREQTKQ
1550
1551
VEELSKKLAD SDQASKVQQQ KLKAVQAQGG ESQQEAQRLQ AQLNELQAQL
1600
1601
SQKEQAAEHY KLQMEKAKTH YDAKKQQNQE LQEQLRSLEQ LQKENKELRA
1650
1651
EAERLGHELQ QAGLKTKEAE QTCRHLTAQV RSLEAQVAHA DQQLRDLGKF
1700
1701
QVATDALKSR EPQAKPQLDL SIDSLDLSCE EGTPLSITSK LPRTQPDGTS
1750
1751
VPGEPASPIS QRLPPKVESL ESLYFTPIPA RSQAPLESSL DSLGDVFLDS
1800
1801
GRKTRSARRR TTQIINITMT KKLDVEEPDS ANSSFYSTRS APASQASLRA
1850
1851
TSSTQSLARL GSPDYGNSAL LSLPGYRPTT RSSARRSQAG VSSGAPPGRN
1900
1901
SFYMGTCQDE PEQLDDWNRI AELQQRNRVC PPHLKTCYPL ESRPSLSLGT
1950
1951
ITDEEMKTGD PQETLRRASM QPIQIAEGTG ITTRQQRKRV SLEPHQGPGT
2000
2001
PESKKATSCF PRPMTPRDRH EGRKQSTTEA QKKAAPASTK QADRRQSMAF
2050
2051
SILNTPKKLG NSLLRRGASK KALSKASPNT RSGTRRSPRI ATTTASAATA
2100
2101
AAIGATPRAK GKAKH                                      
2115
 

Show the unformatted sequence.

Checksums:
CRC64:DE734EC85B812CC7
MD5:b0fb751461b3850f650061df636ee305

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.