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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: FRPD4_HUMAN (Q14CM0)

Summary

This is the summary of UniProt entry FRPD4_HUMAN (Q14CM0).

Description: FERM and PDZ domain-containing protein 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1322 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 17 27
disorder n/a 33 34
disorder n/a 72 74
Pfam PDZ 78 152
disorder n/a 102 108
disorder n/a 115 116
low_complexity n/a 260 274
Pfam FERM_M 294 424
disorder n/a 526 548
disorder n/a 572 575
disorder n/a 583 584
disorder n/a 606 619
disorder n/a 635 642
disorder n/a 669 677
disorder n/a 685 687
disorder n/a 695 696
disorder n/a 701 704
disorder n/a 736 761
low_complexity n/a 742 753
disorder n/a 765 768
disorder n/a 773 774
disorder n/a 777 802
disorder n/a 809 867
low_complexity n/a 816 829
disorder n/a 872 1009
low_complexity n/a 902 915
low_complexity n/a 909 921
disorder n/a 1024 1082
low_complexity n/a 1041 1054
disorder n/a 1090 1148
low_complexity n/a 1120 1133
disorder n/a 1155 1181
disorder n/a 1202 1219
low_complexity n/a 1220 1233
disorder n/a 1221 1223
disorder n/a 1242 1244
disorder n/a 1251 1282
disorder n/a 1284 1292
disorder n/a 1297 1299
disorder n/a 1309 1310

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14CM0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDVFSFVKIA KLSSHRTKSS GWPPPSGTWG LSQVPPYGWE MTANRDGRDY
50
51
FINHMTQAIP FDDPRLESCQ IIPPAPRKVE MRRDPVLGFG FVAGSEKPVV
100
101
VRSVTPGGPS EGKLIPGDQI VMINDEPVSA APRERVIDLV RSCKESILLT
150
151
VIQPYPSPKS AFISAAKKAR LKSNPVKVRF SEEVIINGQV SETVKDNSLL
200
201
FMPNVLKVYL ENGQTKSFRF DCSTSIKDVI LTLQEKLSIK GIEHFSLMLE
250
251
QRTEGAGTKL LLLHEQETLT QVTQRPSSHK MRCLFRISFV PKDPIDLLRR
300
301
DPVAFEYLYV QSCNDVVQER FGPELKYDIA LRLAALQMYI ATVTTKQTQK
350
351
ISLKYIEKEW GLETFLPSAV LQSMKEKNIK KALSHLVKAN QNLVPPGKKL
400
401
SALQAKVHYL KFLSDLRLYG GRVFKATLVQ AEKRSEVTLL VGPRYGISHV
450
451
INTKTNLVAL LADFSHVNRI EMFSEEESLV RVELHVLDVK PITLLMESSD
500
501
AMNLACLTAG YYRLLVDSRR SIFNMANKKN TATQETGPEN KGKHNLLGPD
550
551
WNCIPQMTTF IGEGEQEAQI TYIDSKQKTV EITDSTMCPK EHRHLYIDNA
600
601
YSSDGLNQQL SQPGEAPCEA DYRSLAQRSL LTLSGPETLK KAQESPRGAK
650
651
VSFIFGDFAL DDGISPPTLG YETLLDEGPE MLEKQRNLYI GSANDMKGLD
700
701
LTPEAEGIQF VENSVYANIG DVKSFQAAEG IEEPLLHDIC YAENTDDAED
750
751
EDEVSCEEDL VVGEMNQPAI LNLSGSSDDI IDLTSLPPPE GDDNEDDFLL
800
801
RSLNMAIAAP PPGFRDSSDE EDSQSQAASF PEDKEKGSSL QNDEIPVSLI
850
851
DAVPTSAEGK CEKGLDNAVV STLGALEALS VSEEQQTSDN SGVAILRAYS
900
901
PESSSDSGNE TNSSEMTESS ELATAQKQSE NLSRMFLATH EGYHPLAEEQ
950
951
TEFPASKTPA GGLPPKSSHA LAARPATDLP PKVVPSKQLL HSDHMEMEPE
1000
1001
TMETKSVTDY FSKLHMGSVA YSCTSKRKSK LADGEGKAPP NGNTTGKKQQ
1050
1051
GTKTAEMEEE ASGKFGTVSS RDSQHLSTFN LERTAFRKDS QRWYVATEGG
1100
1101
MAEKSGLEAA TGKTFPRASG LGAREAEGKE EGAPDGETSD GSGLGQGDRF
1150
1151
LTDVTCASSA KDLDNPEDAD SSTCDHPSKL PEADESVARL CDYHLAKRMS
1200
1201
SLQSEGHFSL QSSQGSSVDA GCGTGSSGSA CATPVESPLC PSLGKHLIPD
1250
1251
ASGKGVNYIP SEERAPGLPN HGATFKELHP QTEGMCPRMT VPALHTAINT
1300
1301
EPLFGTLRDG CHRLPKIKET TV                              
1322
 

Show the unformatted sequence.

Checksums:
CRC64:79B73E41B89E2D08
MD5:a23bb644cc5266d266ad70fecc513144

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FERM_M 294 - 424 7BYJ A 294 - 424 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.