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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BRD3_HUMAN (Q15059)

Summary

This is the summary of UniProt entry BRD3_HUMAN (Q15059).

Description: Bromodomain-containing protein 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 726 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 5 35
low_complexity n/a 16 33
disorder n/a 37 38
Pfam Bromodomain 42 128
disorder n/a 144 199
low_complexity n/a 149 163
disorder n/a 201 307
low_complexity n/a 208 249
low_complexity n/a 246 261
Pfam Bromodomain 315 403
disorder n/a 356 370
disorder n/a 412 413
disorder n/a 415 621
low_complexity n/a 419 431
low_complexity n/a 436 460
coiled_coil n/a 463 483
low_complexity n/a 483 540
coiled_coil n/a 487 521
low_complexity n/a 564 568
Pfam BET 571 635
disorder n/a 629 633
disorder n/a 637 726
low_complexity n/a 646 657
coiled_coil n/a 650 678
low_complexity n/a 650 673
low_complexity n/a 692 725

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15059. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL
50
51
WKHQFAWPFY QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE
100
101
CMQDFNTMFT NCYIYNKPTD DIVLMAQALE KIFLQKVAQM PQEEVELLPP
150
151
APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA TPFQSVPPTV SQTPVIAATP
200
201
VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK GVKRKADTTT
250
251
PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ
300
301
HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD
350
351
IIKHPMDLST VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM
400
401
ARKLQDVFEM RFAKMPDEPV EAPALPAPAA PMVSKGAESS RSSEESSSDS
450
451
GSSDSEEERA TRLAELQEQL KAVHEQLAAL SQAPVNKPKK KKEKKEKEKK
500
501
KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA NSTTTAGRQL
550
551
KKGGKQASAS YDSEEEEEGL PMSYDEKRQL SLDINRLPGE KLGRVVHIIQ
600
601
SREPSLRDSN PDEIEIDFET LKPTTLRELE RYVKSCLQKK QRKPFSASGK
650
651
KQAAKSKEEL AQEKKKELEK RLQDVSGQLS SSKKPARKEK PGSAPSGGPS
700
701
RLSSSSSSES GSSSSSGSSS DSSDSE                          
726
 

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Checksums:
CRC64:64F526FC3C1033AA
MD5:b946c4c397f75fdd24b1c5acba15efa0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BET 571 - 635 6BGG B 571 - 635 NGL View in InterPro
6BGH A 571 - 635 NGL View in InterPro
Bromodomain 315 - 403 2E7N A 17 - 105 NGL View in InterPro
2OO1 A 315 - 403 NGL View in InterPro
B 315 - 403 NGL View in InterPro
C 315 - 403 NGL View in InterPro
D 315 - 403 NGL View in InterPro
3S92 A 315 - 403 NGL View in InterPro
5A7C A 315 - 403 NGL View in InterPro
B 315 - 403 NGL View in InterPro
C 315 - 403 NGL View in InterPro
D 315 - 403 NGL View in InterPro
5HFR A 315 - 403 NGL View in InterPro
B 315 - 403 NGL View in InterPro
C 315 - 403 NGL View in InterPro
D 315 - 403 NGL View in InterPro
5HJC A 315 - 403 NGL View in InterPro
6ULP A 315 - 403 NGL View in InterPro
B 315 - 403 NGL View in InterPro
42 - 128 2NXB A 42 - 128 NGL View in InterPro
B 42 - 128 NGL View in InterPro
2YW5 A 42 - 128 NGL View in InterPro
3S91 A 42 - 128 NGL View in InterPro
6QJU A 42 - 128 NGL View in InterPro
B 42 - 128 NGL View in InterPro
6U4A A 42 - 128 NGL View in InterPro
B 42 - 128 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.